Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26414498 | 0.76 | TAS1R3 (0.38) | LMNAHTTRAB9AMEN1KMT2A | |
| SCHEMBL26017064 | 0.76 | — | — | |
| SCHEMBL18031512 | 0.70 | HTT (0.61) | LMNAMAPK1HTTRAB9AMEN1 | |
| SCHEMBL14896680 | 0.69 | HDAC1 (0.46) | ALDH1A1HDAC1HDAC6 | |
| SCHEMBL17184635 | 0.69 | LMNA (0.50) | LMNAMAPK1HTTRAB9AMEN1 | |
| SCHEMBL25721432 | 0.67 | PRSS1 (0.57) | RAB9AMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL22241297 | 0.66 | ACHE (0.44) | LMNAMAPK1HTTRAB9AMEN1 | |
| SCHEMBL14951058 | 0.65 | CYP3A4 (0.52) | LMNAMAPK1HTTRAB9AMEN1 | |
| SCHEMBL524923 | 0.65 | MAPT (0.40) | LMNAMAPK1HTTRAB9AMEN1 | |
| SCHEMBL18685203 | 0.65 | CA12 (0.53) | LMNAMAPK1HTTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4227304-A2 | THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS | Novartis AG (CH) | 2023-08-16 | — | — | EP | disclosed |