SCHEMBL2601928

SCHEMBL2601928

O=C1c2ccccc2C(=O)c2cc(COc3ccc4ccccc4c3)ccc21

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.58
RAB9A P51151 4/20 0.52
MRGPRX4 Q96LA9 1/20 0.52
NPC1 O15118 4/20 0.51
MAPT P10636 3/20 0.51
ALDH1A1 P00352 1/20 0.50
LMNA P02545 1/20 0.50
MAPK1 P28482 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
MAOB P27338 6/20 0.48
MAOA P21397 5/20 0.48
TOP1 P11387 1/20 0.47
TLR4 O00206 1/20 0.46
TLR2 O60603 1/20 0.46
TDP1 Q9NUW8 1/20 0.45
AGXT P21549 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2601920 0.84 NPC1 (0.56) RAB9ANPC1MAPTALDH1A1LMNA
SCHEMBL2601925 0.82 MRGPRX4 (0.54) ALOX5RAB9AMRGPRX4NPC1MAPT
SCHEMBL2601922 0.82 ELANE (0.54) RAB9ANPC1MAPTALDH1A1LMNA
SCHEMBL2601924 0.82 MAPT (0.68) RAB9ANPC1MAPTALDH1A1LMNA
SCHEMBL2601921 0.82 MAOB (0.56) RAB9ANPC1MAPTALDH1A1LMNA
SCHEMBL12938497 0.82 ALOX5 (0.78) ALOX5RAB9AMRGPRX4NPC1MAPT
SCHEMBL28441355 0.79 MAPT (0.56) RAB9ANPC1MAPTALDH1A1LMNA
SCHEMBL24701048 0.79 TOP1 (0.71) ALOX5RAB9ANPC1ALDH1A1LMNA
SCHEMBL2601923 0.78 APP (0.52) RAB9ANPC1MAPTALDH1A1LMNA
SCHEMBL562544 0.76 TOP1 (0.67) ALOX5RAB9ANPC1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8956519-B2 Device for detecting an analyte SENOVA SYSTEMS, INC. (US) 2015-02-17 US disclosed
US-8956519-B2 Device for detecting an analyte SENOVA SYSTEMS, INC. (US) 2015-02-17 US disclosed
US-20120090995-A1 DEVICE FOR DETECTING AN ANALYTE SENOVA SYSTEMS, INC. (US) 2012-04-19 US disclosed
US-20120090995-A1 DEVICE FOR DETECTING AN ANALYTE SENOVA SYSTEMS, INC. (US) 2012-04-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120090995-A1 DEVICE FOR DETECTING AN ANALYTE GPX4, GPX1, AOX1 ALOX5 1784/4885RAB9A 3669/4885MRGPRX4 2310/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.