Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30404865 | 0.88 | BMPR1B (0.42) | BACE1ALDH1A1MAPTKMT2AMTOR | |
| SCHEMBL21001814 | 0.88 | BMPR1B (0.42) | BACE1ALDH1A1MAPTKMT2AMTOR | |
| SCHEMBL30507436 | 0.82 | HDAC1 (0.36) | ALDH1A1MAPTKMT2ABMPR1BBMPR1A | |
| SCHEMBL25318355 | 0.82 | HDAC1 (0.36) | ALDH1A1MAPTKMT2ABMPR1BBMPR1A | |
| SCHEMBL2051397 | 0.77 | BMPR1B (0.50) | BMPR1BBMPR1AACVRL1ACVR1PDE4B | |
| SCHEMBL30404193 | 0.77 | BMPR1B (0.50) | BMPR1BBMPR1AACVRL1ACVR1PDE4B | |
| SCHEMBL30062474 | 0.77 | PARK7 (0.46) | ALDH1A1MAPTKMT2AHDAC1HDAC8 | |
| SCHEMBL27138647 | 0.77 | PARK7 (0.46) | ALDH1A1MAPTKMT2AHDAC1HDAC8 | |
| SCHEMBL25316939 | 0.76 | HDAC1 (0.34) | BACE1ALDH1A1MAPTBMPR1BBMPR1A | |
| SCHEMBL30506707 | 0.76 | HDAC1 (0.34) | BACE1ALDH1A1MAPTBMPR1BBMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | HERCULES CAPITAL, INC., AS AGENT | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | APOL1, APOB, LDLR | BACE1 35/4885ALDH1A1 2642/4885MAPT 244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.