Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | NQO2 | P16083 | 6/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL110643 | 0.85 | KDM4E (0.53) | KDM4EALDH1A1HPGDNQO2ABL1 | |
| SCHEMBL29678780 | 0.85 | KDM4E (0.53) | KDM4EALDH1A1HPGDNQO2ABL1 | |
| SCHEMBL22902580 | 0.84 | IKBKB (0.53) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL21349339 | 0.83 | KDM4E (0.47) | KDM4EALDH1A1HPGDNQO2ABL1 | |
| SCHEMBL31310191 | 0.83 | KDM4E (0.56) | KDM4EALDH1A1HPGDNQO2POLB | |
| SCHEMBL26040458 | 0.82 | NQO2 (0.46) | KDM4EALDH1A1HPGDNQO2ABL1 | |
| SCHEMBL26040461 | 0.81 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDPOLBHSD17B10 | |
| SCHEMBL21216359 | 0.81 | POLB (0.58) | ALDH1A1NQO2POLBMAPK1SMN1; SMN2 | |
| SCHEMBL25360994 | 0.80 | KDM4E (0.54) | KDM4EALDH1A1HPGDNQO2POLB | |
| SCHEMBL26040462 | 0.80 | POLB (0.45) | KDM4EALDH1A1HPGDPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |