Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.42 |
| ▸ | GABRD | O14764 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.42 |
| ▸ | GABRE | P78334 | 2/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21216359 | 0.85 | POLB (0.58) | ALDH1A1SMN1; SMN2MAPK1POLBCYP3A4 | |
| SCHEMBL21326570 | 0.81 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MAPK1POLBKDM4E | |
| SCHEMBL30104719 | 0.81 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MAPK1POLBKDM4E | |
| SCHEMBL30232992 | 0.81 | KEAP1 (0.48) | ALDH1A1SMN1; SMN2MAPK1POLBKDM4E | |
| SCHEMBL1945483 | 0.81 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPK1POLBKDM4E | |
| SCHEMBL535587 | 0.81 | KEAP1 (0.48) | ALDH1A1SMN1; SMN2MAPK1POLBKDM4E | |
| SCHEMBL1890350 | 0.81 | KDM4E (0.50) | ALDH1A1SMN1; SMN2MAPK1POLBKDM4E | |
| SCHEMBL5256305 | 0.81 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPK1POLBKDM4E | |
| SCHEMBL31264177 | 0.81 | KDM4E (0.50) | ALDH1A1SMN1; SMN2MAPK1POLBKDM4E | |
| SCHEMBL26040462 | 0.81 | POLB (0.45) | ALDH1A1SMN1; SMN2MAPK1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118908957-A | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-114222737-B | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-07-26 | — | — | CN | disclosed |
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| CN-114867725-A | OGA inhibitor compounds | 詹森药业有限公司 | 2022-08-05 | — | — | CN | disclosed |