Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26046414 | 0.88 | IAPP (0.44) | POLBHPGDLMNAMCL1HSD17B10 | |
| SCHEMBL11724939 | 0.84 | HSD17B10 (0.51) | POLBHPGDLMNAMCL1HSD17B10 | |
| SCHEMBL21317654 | 0.84 | POLB (0.55) | POLBHPGDLMNAFFAR1FFAR4 | |
| SCHEMBL21317653 | 0.81 | POLB (0.53) | POLBHPGDLMNAFFAR1FFAR4 | |
| SCHEMBL29452317 | 0.81 | HMGCR (0.47) | HPGDLMNAMCL1HSD17B10ALOX5 | |
| SCHEMBL26046491 | 0.81 | HMGCR (0.47) | HPGDLMNAMCL1HSD17B10ALOX5 | |
| SCHEMBL26046334 | 0.80 | LMNA (0.47) | POLBHPGDLMNAFFAR1NPSR1 | |
| SCHEMBL26046355 | 0.80 | POLB (0.55) | POLBFFAR1FFAR4GAANPSR1 | |
| SCHEMBL26046352 | 0.79 | POLB (0.45) | POLBHPGDFFAR1FFAR4HSD17B10 | |
| SCHEMBL21317656 | 0.78 | TDP1 (0.54) | POLBLMNAFFAR1FFAR4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |