Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452317 | 1.00 | HMGCR (0.47) | HMGCRALOX5PTGS2ELANEGABRA1 | |
| SCHEMBL26046492 | 0.82 | ALOX5 (0.54) | HMGCRALOX5PTGS2ELANEGABRA1 | |
| SCHEMBL26046358 | 0.81 | POLB (0.50) | ALOX5PTGESMCL1KDM4ELMNA | |
| SCHEMBL26046414 | 0.81 | IAPP (0.44) | ALOX5PTGS2PTGESMCL1KDM4E | |
| SCHEMBL9153690 | 0.80 | PRKCI (0.42) | HMGCRALOX5ELANEGABRA1GABRB2 | |
| SCHEMBL292318 | 0.79 | ALOX5 (0.57) | ALOX5PTGS2ELANEPTGES | |
| SCHEMBL16670384 | 0.79 | HMGCR (0.50) | HMGCRALOX5PTGS2ELANEGABRA1 | |
| SCHEMBL26046465 | 0.78 | PRKCI (0.49) | HMGCRALOX5ELANEKDM4EALDH1A1 | |
| SCHEMBL26046475 | 0.77 | PTGS2 (0.50) | HMGCRALOX5PTGS2ELANEKDM4E | |
| SCHEMBL11724939 | 0.77 | HSD17B10 (0.51) | MCL1KDM4EALDH1A1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |