Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26051147 | 0.80 | AR (0.51) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL12219870 | 0.78 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL12086425 | 0.78 | LMNA (0.47) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL16558715 | 0.77 | ALOX15 (0.47) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL27843089 | 0.73 | AR (0.42) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL31596098 | 0.73 | ALDH1A1 (0.54) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL2340680 | 0.72 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL2334075 | 0.69 | PIK3CA (0.51) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL28003501 | 0.68 | KMT2A (0.44) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL20365562 | 0.68 | TACR2 (0.39) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164233-A1 | (4-BENZO[D]OXAZOL-2-YL)-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-YL)METHANONE DERIVATIVES AS MUTANT PAH STABILIZERS FOR THE TREATMENT OF PHENYLKETONURIA | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023164237-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |