Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12086425 | 0.81 | LMNA (0.47) | ARPIK3CDPIK3CAPIK3CBSMN1; SMN2 | |
| SCHEMBL26051145 | 0.80 | PIK3CD (0.40) | ARPIK3CDPIK3CAPIK3CBSMN1; SMN2 | |
| SCHEMBL4850658 | 0.78 | PIK3CD (0.61) | ARPIK3CDPIK3CAPIK3CBSMN1; SMN2 | |
| SCHEMBL31596098 | 0.77 | ALDH1A1 (0.54) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL27843089 | 0.77 | AR (0.42) | ARPIK3CDPIK3CAPIK3CBSMN1; SMN2 | |
| SCHEMBL2340680 | 0.76 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL2334075 | 0.75 | PIK3CA (0.51) | PIK3CDPIK3CAPIK3CBSMN1; SMN2KDM4E | |
| SCHEMBL16561758 | 0.75 | AR (0.55) | ARPIK3CDPIK3CAPIK3CBSMN1; SMN2 | |
| SCHEMBL28003504 | 0.72 | AR (0.52) | ARPIK3CDPIK3CAPIK3CBSMN1; SMN2 | |
| SCHEMBL4845510 | 0.71 | AR (0.51) | ARPIK3CDPIK3CAPIK3CBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164237-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |