Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | CDK4 | P11802 | 4/20 | 0.41 |
| ▸ | CCND1 | P24385 | 4/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430655 | 0.85 | ALDH1A1 (0.46) | HTR7CDK4CCND1CDC7CDK2 | |
| SCHEMBL24216449 | 0.84 | HTR7 (0.56) | HTR7CDC7CDK2HTR2AHTR2C | |
| SCHEMBL8434667 | 0.76 | HTR2C (0.56) | HTR7CDK4CCND1HTR2AHTR2C | |
| SCHEMBL27812843 | 0.76 | CDK4 (0.44) | CDK4CCND1MCL1HTR2AHTR2C | |
| SCHEMBL8430623 | 0.76 | KMO (0.59) | HTR7CDK4CCND1MCL1HTR2A | |
| SCHEMBL4651648 | 0.76 | KDM4E (0.53) | CDK4CCND1MCL1HTR2AHTR2C | |
| SCHEMBL19526836 | 0.76 | HTR7 (0.57) | HTR7CDK4CCND1MCL1HTR2A | |
| SCHEMBL18029368 | 0.75 | HTR7 (0.49) | HTR7CDC7CDK2 | |
| SCHEMBL8430662 | 0.75 | ALDH1A1 (0.48) | HTR7CDC7CDK2HTR2AHTR2C | |
| SCHEMBL25154223 | 0.74 | HTR7 (0.56) | HTR7CDK4CCND1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3931188-B1 | NEW ISOINDOLINONE SUBSTITUTED INDOLES AND DERIVATIVES AS RAS INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2023-08-30 | — | — | EP | disclosed |