Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 6/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26053476 | 0.88 | TPH1 (0.42) | TPH1MAPTMEN1CYP1A2CYP3A4 | |
| SCHEMBL26053265 | 0.87 | HPGD (0.46) | TPH1MAPTPDE10AUBE2MDCUN1D1 | |
| SCHEMBL26054535 | 0.87 | AOC3 (0.39) | TPH1MAPTPDE10AUBE2MDCUN1D1 | |
| SCHEMBL26054666 | 0.86 | TPH1 (0.38) | TPH1MAPTPDE10AMEN1CYP1A2 | |
| SCHEMBL26054669 | 0.85 | TPH1 (0.38) | TPH1MAPTPDE10AMEN1CYP1A2 | |
| SCHEMBL26053709 | 0.85 | UBE2M (0.44) | TPH1MAPTMEN1CYP1A2CYP3A4 | |
| SCHEMBL26053711 | 0.84 | TPH1 (0.41) | TPH1MAPTUBE2MDCUN1D1LMNA | |
| SCHEMBL31675781 | 0.83 | AOC3 (0.38) | AOC3 | |
| SCHEMBL26053579 | 0.83 | TPH1 (0.41) | TPH1MAPTUBE2MDCUN1D1LMNA | |
| SCHEMBL26053269 | 0.83 | CASP3 (0.44) | TPH1MAPTUBE2MDCUN1D1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164237-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |