Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.35 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.35 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2606378 | 0.86 | EPHX2 (0.40) | ALDH1A1DPP4EPHX2KMT2ASMN1; SMN2 | |
| SCHEMBL9072449 | 0.84 | EPHX2 (0.51) | ALDH1A1CYP3A4EPHX2KMT2ASMN1; SMN2 | |
| SCHEMBL2606369 | 0.81 | GNAI3 (0.42) | ALDH1A1EPHX2KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2606484 | 0.80 | NPC1 (0.40) | ALDH1A1KMT2AHSD11B1MEN1ATM | |
| SCHEMBL2606486 | 0.80 | HSD11B1 (0.54) | ALDH1A1FAAHTPSAB1TPSD1TPSG1 | |
| SCHEMBL2606449 | 0.80 | KMT2A (0.43) | ALDH1A1KMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL10272978 | 0.80 | MEN1 (0.43) | ALDH1A1EPHX2KMT2AMEN1ATM | |
| SCHEMBL2606418 | 0.79 | TPSAB1 (0.45) | ALDH1A1DPP4FAAHTPSAB1TPSD1 | |
| SCHEMBL2666140 | 0.79 | GNAI3 (0.50) | ALDH1A1KMT2AMAPTHSD11B1MEN1 | |
| SCHEMBL2606343 | 0.79 | HTT (0.48) | ALDH1A1DPP4EPHX2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102516240-A | Heteroaryl-ureas and their use as glucokinase activators | NOVO NORDISK AS | 2012-06-27 | — | — | CN | disclosed |
| EP-2444397-A1 | Heteroaryl-ureas and their use as glucokinase activators | Novo Nordisk A/S (DK) | 2012-04-25 | — | — | EP | disclosed |
| CN-1910166-B | Heteroaryl ureas and their use as glucokinase activators | NOVO NORDISK AS | 2012-01-04 | — | — | CN | disclosed |