Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 6/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666140 | 0.84 | GNAI3 (0.50) | NPC1GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL2606369 | 0.81 | GNAI3 (0.42) | NPC1GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL2606486 | 0.80 | HSD11B1 (0.54) | ALDH1A1HSD11B1MEN1KMT2AATM | |
| SCHEMBL2606485 | 0.80 | ALDH1A1 (0.41) | ALDH1A1HSD11B1MEN1KMT2AATM | |
| SCHEMBL9072449 | 0.78 | EPHX2 (0.51) | ALDH1A1HSD11B1MEN1KMT2A | |
| SCHEMBL2606383 | 0.78 | ALDH1A1 (0.42) | NPC1ALDH1A1HSD11B1MEN1KMT2A | |
| SCHEMBL2606380 | 0.77 | GNAI3 (0.36) | NPC1GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL2606469 | 0.76 | L3MBTL1 (0.46) | ALDH1A1HSD11B1MEN1KMT2AL3MBTL1 | |
| SCHEMBL10272978 | 0.75 | MEN1 (0.43) | ALDH1A1MEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL2606378 | 0.75 | EPHX2 (0.40) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444397-A1 | Heteroaryl-ureas and their use as glucokinase activators | Novo Nordisk A/S (DK) | 2012-04-25 | — | — | EP | disclosed |