SCHEMBL26070599

SCHEMBL26070599

N#C/C(N)=C(/N)c1c[nH]c(-c2ccccc2)n1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTOR P42345 1/20 0.35
ADK P55263 1/20 0.35
NISCH Q9Y2I1 1/20 0.35
CYP1A2 P05177 4/20 0.34
KDM4E B2RXH2 3/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 1/20 0.34
ALDH1A1 P00352 4/20 0.33
HPGD P15428 2/20 0.33
CHUK O15111 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
LRRK2 Q5S007 2/20 0.33
MCL1 Q07820 2/20 0.33
HPGDS O60760 1/20 0.33
MAPK13 O15264 1/20 0.32
RAF1 P04049 1/20 0.32
MAPK12 P53778 1/20 0.32
MAPK11 Q15759 1/20 0.32
MAPK14 Q16539 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1079995 0.77 ALDH1A1 (0.49) CYP1A2KDM4ECYP2C19ALDH1A1HPGD
SCHEMBL7231545 0.76 PRSS1 (0.44) MTORADKNISCHCYP1A2KDM4E
SCHEMBL3735844 0.76 DCUN1D1 (0.39) MTORADKNISCHCYP1A2KDM4E
SCHEMBL26070627 0.74 MAPT (0.42) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL1080850 0.72 PIN1 (0.47) CYP1A2KDM4ECYP2C19ALDH1A1HPGD
SCHEMBL811735 0.70 MAPT (0.46) CYP1A2KDM4ECYP2C19ALDH1A1HPGD
Hydrochloric Acid SCHEMBL6861539 0.70 PIN1 (0.46) CYP1A2KDM4ECYP2C19ALDH1A1HPGD
SCHEMBL26070610 0.70 HDAC1 (0.50) CYP1A2KDM4ECYP2C9CYP2C19ALDH1A1
SCHEMBL2790613 0.69 DCUN1D1 (0.39) MTORADKNISCHCYP1A2KDM4E
SCHEMBL6861535 0.69 PIN1 (0.41) MTORADKNISCHCYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4219477-A1 CYANOTRIAZOLE COMPOUNDS Otsuka Pharmaceutical Co., Ltd. (JP) 2023-08-02 EP disclosed