Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26075234 | 0.92 | DHODH (0.44) | DHODHPLA2G2APDE10A | |
| SCHEMBL26075237 | 0.92 | PLA2G2A (0.44) | DHODHPLA2G2APDE10AKCNH2HRH3 | |
| SCHEMBL26075130 | 0.92 | HMOX1 (0.43) | DHODHPLA2G2APDE10AHMOX1 | |
| SCHEMBL26075327 | 0.91 | SQOR (0.42) | DHODHPLA2G2AKCNH2HRH3 | |
| SCHEMBL26075902 | 0.90 | NCF1 (0.37) | DHODHPLA2G2ANCF1PDE10APDE3B | |
| SCHEMBL26075277 | 0.90 | PLA2G2A (0.42) | DHODHPLA2G2APDE10AKCNH2HRH3 | |
| SCHEMBL26075343 | 0.89 | PLA2G2A (0.39) | DHODHPLA2G2ANCF1PDE10AKCNH2 | |
| SCHEMBL26075280 | 0.89 | PDE2A (0.44) | DHODHPLA2G2APDE10AKCNH2HRH3 | |
| SCHEMBL26075247 | 0.89 | PDE2A (0.44) | DHODHPLA2G2APDE10AKCNH2HRH3 | |
| SCHEMBL26075283 | 0.89 | PDE2A (0.44) | DHODHPLA2G2APDE10AKCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303710-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2023-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303710-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | DHODH, CD38, DPYD | DHODH 1/4885PLA2G2A 1679/4885NCF1 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.