Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | CA12 | O43570 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | CA9 | Q16790 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | BRD4 | O60885 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | MB | P02144 | 1/20 | 0.59 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.59 |
| ▸ | CA3 | P07451 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18880072 | 0.91 | ALDH1A1 (0.73) | MAPTKMT2AALDH1A1MEN1RXFP1 | |
| SCHEMBL3167613 | 0.83 | TAAR1 (0.66) | MAPTKMT2AALDH1A1MEN1RXFP1 | |
| SCHEMBL6834723 | 0.83 | MAPT (0.55) | MAPTKMT2AALDH1A1MEN1RXFP1 | |
| SCHEMBL13390897 | 0.83 | KMT2A (0.63) | MAPTKMT2AALDH1A1MEN1RXFP1 | |
| SCHEMBL8691196 | 0.83 | ALDH1A1 (0.63) | MAPTKMT2AALDH1A1MEN1RXFP1 | |
| SCHEMBL178429 | 0.83 | MAPT (0.71) | MAPTKMT2AALDH1A1MEN1RXFP1 | |
| SCHEMBL22759117 | 0.82 | MAPT (0.53) | MAPTKMT2AALDH1A1MEN1RXFP1 | |
| SCHEMBL26885117 | 0.81 | ALDH1A1 (0.57) | MAPTKMT2AALDH1A1MEN1RXFP1 | |
| SCHEMBL5227347 | 0.81 | ALDH1A1 (0.61) | MAPTKMT2AALDH1A1MEN1RXFP1 | |
| SCHEMBL10819622 | 0.81 | KMT2A (0.80) | MAPTKMT2AALDH1A1MEN1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210332001-A1 | SYNTHESIS AND ANTI-TUMOR ACTIVITIES OF ACYL-PARA-AMINOPHENOL DERIVATIVES | MONTEFIORE MEDICAL CENTER | 2021-10-28 | — | — | US | claimed |
| US-20230339910-A1 | RAS INHIBITORS AND METHODS OF USING THE SAME | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2023-10-26 | — | — | US | disclosed |
| US-20230339910-A1 | RAS INHIBITORS AND METHODS OF USING THE SAME | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2023-10-26 | — | — | US | disclosed |
| US-20210332001-A1 | SYNTHESIS AND ANTI-TUMOR ACTIVITIES OF ACYL-PARA-AMINOPHENOL DERIVATIVES | MONTEFIORE MEDICAL CENTER | 2021-10-28 | — | — | US | disclosed |
| US-20210332001-A1 | SYNTHESIS AND ANTI-TUMOR ACTIVITIES OF ACYL-PARA-AMINOPHENOL DERIVATIVES | MONTEFIORE MEDICAL CENTER | 2021-10-28 | — | — | US | disclosed |
| US-20210161869-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-06-03 | — | — | US | disclosed |
| US-10966967-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-04-06 | — | — | US | disclosed |
| CN-112154149-A | Novel vinylphosphines and photoinitiators obtainable therefrom | 汉斯约尔格·格吕茨马赫 | 2020-12-29 | — | — | CN | disclosed |
| US-20200281905-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-09-10 | — | — | US | disclosed |
| US-10695328-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-06-30 | — | — | US | disclosed |
| US-20080160445-A1 | Planographic printing plate material, and method of preparing planographic printing plate employing the same | KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) | 2008-07-03 | — | — | US | disclosed |
| US-7378522-B2 | Such as 6-(4-Acetamidophenoxy)-5-(N-benzyl-N-methylaminomethyl)-1-(2',6'-difluorobenzyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid-ethyl ester; rapid effectiveness, bioavailability; low cost, simple synthesis | ZENTARIS AG (DE) | 2008-05-27 | — | — | US | disclosed |
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| US-20050004127-A1 | Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone | AETERNA ZENTARIS GMBH (DE) | 2005-01-06 | — | — | US | disclosed |
| US-6790858-B2 | HIGH EFFECTIVENESS AND HIGH ORAL BIOAVAILABILITY; FOR EXAMPLE, 6-(4-ACETAMIDOPHENYL)-3-ISOBUTYRYL-5-(N-BENZYL-N-METHYLAMINOMETHYL)-1-(2',6'-DIFLUOROBENZYL)-1,4-DIHYDRO-4-OXOQUINOLINE | ZENTARIS AG (DE) | 2004-09-14 | — | — | US | disclosed |
| CN-1496354-A | Quinoline, isoquinoline and phthalazine derivatives as antagonists of gonadotropin-releasing hormone | — | 2004-05-12 | — | — | CN | disclosed |
| EP-1362034-A1 | QUINOLINE, ISOQUINOLINE AND PHTHALAZINE DERIVATIVES AS ANTAGONISTS OF THE GONADOTROPIN-RELEASING HORMONE | Schering Aktiengesellschaft (DE) | 2003-11-19 | — | — | EP | disclosed |
| US-20030105328-A1 | Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone | SCHERING AG (DE) | 2003-06-05 | — | — | US | disclosed |
| WO-2002066437-A1 | QUINOLINE, ISOQUINOLINE AND PHTHALAZINE DERIVATIVES AS ANTAGONISTS OF THE GONADOTROPIN-RELEASING HORMONE | ZENTARIS GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |
| US-3960945-A | 4-[-(Alkoxy or polyhaloalkoxy)-benzamido]cyclohexanones | STERLING DRUG INC. (US) | 1976-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004127-A1 | Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone | GNRHR, LHCGR, PRLHR | MAPT 2391/4885KMT2A 530/4885ALDH1A1 4319/4885 |
| US-20230339910-A1 | RAS INHIBITORS AND METHODS OF USING THE SAME | KRAS, NRAS, HRAS | MAPT 4176/4885KMT2A 2991/4885ALDH1A1 3682/4885 |
| US-20030105328-A1 | Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone | GNRHR, LHCGR, PRLHR | MAPT 2391/4885KMT2A 530/4885ALDH1A1 4319/4885 |
| US-20210332001-A1 | SYNTHESIS AND ANTI-TUMOR ACTIVITIES OF ACYL-PARA-AMINOPHENOL DERIVATIVES | AADAC, FABP7, NPEPPS | MAPT 3049/4885KMT2A 680/4885ALDH1A1 1271/4885 |
| US-20210161869-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | DGAT2, MGAT2, MGAT1 | MAPT 2124/4885KMT2A 155/4885ALDH1A1 284/4885 |
| US-10966967-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | DGAT2, MGAT2, MGAT1 | MAPT 2124/4885KMT2A 155/4885ALDH1A1 284/4885 |
| US-10695328-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | DGAT2, MGAT2, MGAT1 | MAPT 2124/4885KMT2A 155/4885ALDH1A1 284/4885 |
| US-20200281905-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | DGAT2, MGAT2, MGAT1 | MAPT 2124/4885KMT2A 155/4885ALDH1A1 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.