Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17974652 | 0.78 | NPSR1 (0.48) | ALDH1A1CES2ACHECES1ENPP2 | |
| SCHEMBL17857084 | 0.78 | ALDH1A1 (0.46) | ALDH1A1CES2ENPP2TDP1NPSR1 | |
| SCHEMBL27600648 | 0.77 | ALDH1A1 (0.41) | ALDH1A1CES2ACHECES1ENPP2 | |
| SCHEMBL7458876 | 0.75 | ALDH1A1 (0.46) | ALDH1A1CES2ENPP2TDP1NPSR1 | |
| SCHEMBL27600650 | 0.72 | ALDH1A1 (0.38) | ALDH1A1CES2ACHECES1ENPP2 | |
| SCHEMBL18816146 | 0.72 | ALDH1A1 (0.47) | ALDH1A1ENPP2TDP1RAB9ASMN1; SMN2 | |
| SCHEMBL31184606 | 0.72 | ALDH1A1 (0.43) | ALDH1A1ENPP2TDP1NPSR1SMN1; SMN2 | |
| SCHEMBL9550132 | 0.72 | ALDH1A1 (0.43) | ALDH1A1ENPP2TDP1NPSR1SMN1; SMN2 | |
| SCHEMBL2873795 | 0.72 | ALDH1A1 (0.43) | ALDH1A1ENPP2TDP1NPSR1SMN1; SMN2 | |
| SCHEMBL29860136 | 0.72 | ALDH1A1 (0.43) | ALDH1A1CES2ACHECES1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12304915-B2 | SOS1 inhibitors | Mirati Therapeutics, Inc. (US) | 2025-05-20 | — | — | US | disclosed |
| US-20230137886-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12304915-B2 | SOS1 inhibitors | SOS1, SOS2, SAV1 | ALDH1A1 3260/4885CES2 4258/4885ACHE 4429/4885 |
| US-20230137886-A1 | SOS1 INHIBITORS | SOS1, SOS2, SAV1 | ALDH1A1 3260/4885CES2 4258/4885ACHE 4429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.