SCHEMBL29860136

SCHEMBL29860136

CCOC(=O)COc1c([N+](=O)[O-])cccc1C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.43
KDM4E B2RXH2 2/20 0.43
HTT P42858 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
RAB9A P51151 2/20 0.43
MAPT P10636 2/20 0.43
NPC1 O15118 1/20 0.43
S1PR4 O95977 1/20 0.43
LMNA P02545 1/20 0.43
ITGA4 P13612 1/20 0.43
HPGD P15428 1/20 0.43
S1PR1 P21453 1/20 0.43
MAPK1 P28482 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
TLR9 Q9NR96 1/20 0.43
CES2 O00748 1/20 0.42
ACHE P22303 1/20 0.42
CES1 P23141 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
POLB P06746 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3598134 0.87 ALDH1A1 (0.50) ALDH1A1KDM4EHTTSMN1; SMN2RAB9A
SCHEMBL16792371 0.84 NLRP3 (0.48) ALDH1A1KDM4EHTTSMN1; SMN2RAB9A
SCHEMBL11241296 0.82 RAB9A (0.49) ALDH1A1KDM4EHTTSMN1; SMN2RAB9A
SCHEMBL16792345 0.81 PTPN7 (0.53) ALDH1A1KDM4EHTTSMN1; SMN2RAB9A
SCHEMBL30720043 0.79 RAB9A (0.42) ALDH1A1HTTSMN1; SMN2RAB9AMAPT
SCHEMBL2746717 0.78 ALDH1A1 (0.51) ALDH1A1KDM4EHTTSMN1; SMN2MAPT
SCHEMBL13099833 0.78 KDM4E (0.65) ALDH1A1KDM4EHTTSMN1; SMN2RAB9A
SCHEMBL30581469 0.78 KDM4E (0.65) ALDH1A1KDM4EHTTSMN1; SMN2RAB9A
SCHEMBL1508394 0.77 KDM4E (0.45) ALDH1A1KDM4EMAPTLMNAHPGD
SCHEMBL7996901 0.76 ALDH1A1 (0.56) ALDH1A1KDM4EHTTSMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4305042-A1 TRICYCLIC PESTICIDAL COMPOUNDS BASF SE (DE) 2024-01-17 EP disclosed
WO-2022189191-A1 TRICYCLIC PESTICIDAL COMPOUNDS BASF SE (DE) 2022-09-15 WO disclosed