Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31184606 | 1.00 | ALDH1A1 (0.43) | ALDH1A1TDP1GPR35ARP2RX1 | |
| SCHEMBL6225842 | 0.87 | TDP1 (0.39) | ALDH1A1TDP1GPR35P2RX1CYP1A2 | |
| SCHEMBL7458876 | 0.83 | ALDH1A1 (0.46) | ALDH1A1TDP1GPR35ARP2RX1 | |
| SCHEMBL17857084 | 0.83 | ALDH1A1 (0.46) | ALDH1A1TDP1GPR35ARP2RX1 | |
| SCHEMBL9550132 | 0.83 | ALDH1A1 (0.43) | ALDH1A1TDP1GPR35P2RX1CYP1A2 | |
| SCHEMBL18816146 | 0.83 | ALDH1A1 (0.47) | ALDH1A1TDP1GPR35P2RX1CYP1A2 | |
| SCHEMBL3420889 | 0.82 | TDP1 (0.54) | ALDH1A1TDP1GPR35CYP1A2CYP3A4 | |
| SCHEMBL8014629 | 0.81 | ALDH1A1 (0.47) | ALDH1A1TDP1GPR35CYP1A2CYP3A4 | |
| SCHEMBL2882412 | 0.78 | ALDH1A1 (0.40) | ALDH1A1TDP1GPR35P2RX1CYP1A2 | |
| SCHEMBL954085 | 0.78 | TAAR1 (0.43) | ALDH1A1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233862-B1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KBETA INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-07-03 | — | — | EP | disclosed |
| CN-106232572-B | The manufacturing method of nitro compound | 住友化学株式会社 | 2018-11-13 | — | — | CN | disclosed |
| US-10087187-B2 | Imidazopyridazine derivatives as PI3KB inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2018-10-02 | — | — | US | disclosed |
| US-9975844-B2 | Method for producing nitro compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2018-05-22 | — | — | US | disclosed |
| CN-106164041-B | The manufacture method of nitro compound | 住友化学株式会社 | 2018-05-04 | — | — | CN | disclosed |
| US-20180002336-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KB INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-01-04 | — | — | US | disclosed |
| EP-3233862-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS 3 INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2017-10-25 | — | — | EP | disclosed |
| CN-107108634-A | Imidazopyridazine derivatives as PI3K beta inhibitors | 詹森药业有限公司 | 2017-08-29 | — | — | CN | disclosed |
| US-20170129846-A1 | METHOD FOR PRODUCING NITRO COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2017-05-11 | — | — | US | disclosed |
| CN-106232572-A | The manufacture method of nitro compound | 住友化学株式会社 | 2016-12-14 | — | — | CN | disclosed |
| WO-2010103306-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS ANTIVARAL AGENTS | ASTRAZENECA UK LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |
| US-20100029645-A1 | Inhibitors of Cytosolic Phospholipase A2 | WYETH LLC | 2010-02-04 | — | — | US | disclosed |
| US-20100022536-A1 | Inhibitors of Cytosolic Phospholipase A2 | NOVARTIS AG (CH) | 2010-01-28 | — | — | US | disclosed |
| US-7557135-B2 | Inhibitors of cytosolic phospholipase A2 | WYETH (US) | 2009-07-07 | — | — | US | disclosed |
| EP-1891006-A2 | INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | Wyeth a Corporation of the State of Delaware (US) | 2008-02-27 | — | — | EP | disclosed |
| US-20070004719-A1 | Inhibitors of cytosolic phospholipase A2 | WYETH (US) | 2007-01-04 | — | — | US | disclosed |
| WO-2006128142-A2 | INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | WYETH (US) | 2006-11-30 | — | — | WO | disclosed |
| EP-0546697-A1 | Process for the bromination of deactivated toluenes in the benzylic position | AT&T Corp. (US) | 1993-06-16 | — | — | EP | disclosed |
| US-5200544-A | Acid generator, acid sensitive polymer; photosensitivity | AT&T BELL LABORATORIES (US) | 1993-04-06 | — | — | US | disclosed |
| US-5135838-A | Resin sensitive to UV radiation and a nitrobenzyl compound that generates an acid | AT&T BELL LABORATORIES (US) | 1992-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002336-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS PI3KB INHIBITORS | PIK3CB, PIK3CD, PIK3CA | ALDH1A1 1344/4885TDP1 2325/4885GPR35 2100/4885 |
| US-20100022536-A1 | Inhibitors of Cytosolic Phospholipase A2 | PLA2G4B, PLA2G4A, PLA2G12A | ALDH1A1 2405/4885TDP1 1941/4885GPR35 2645/4885 |
| US-20170129846-A1 | METHOD FOR PRODUCING NITRO COMPOUND | NOX1, NOS1, NOX3 | ALDH1A1 451/4885TDP1 2982/4885GPR35 3499/4885 |
| US-20100029645-A1 | Inhibitors of Cytosolic Phospholipase A2 | PLA2G4B, PLA2G4A, PLA2G12A | ALDH1A1 2405/4885TDP1 1941/4885GPR35 2645/4885 |
| US-10087187-B2 | Imidazopyridazine derivatives as PI3KB inhibitors | PIK3CB, PIK3CD, PIK3CA | ALDH1A1 1344/4885TDP1 2325/4885GPR35 2100/4885 |
| US-20070004719-A1 | Inhibitors of cytosolic phospholipase A2 | PLA2G4B, PLA2G4A, PLA2G12A | ALDH1A1 2405/4885TDP1 1941/4885GPR35 2645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.