Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL11408787 | 0.85 | — | — | |
| Bicarbonate SCHEMBL48074 | 0.84 | — | — | |
| Maleic Acid SCHEMBL19691762 | 0.81 | TSHR (0.69) | TSHRTP53EGLN1EGLN3LMNA | |
| Hydrogen Peroxide SCHEMBL27900920 | 0.80 | — | — | |
| Acetic Acid SCHEMBL27972133 | 0.79 | — | — | |
| Carbamic Acid SCHEMBL28133607 | 0.79 | — | — | |
| Fumaric Acid SCHEMBL27327513 | 0.79 | TSHR (0.56) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL27489187 | 0.79 | TSHR (0.56) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL4595774 | 0.79 | TSHR (0.56) | TSHRTP53EGLN1EGLN3LMNA | |
| Acrylic Acid SCHEMBL11407018 | 0.78 | LMNA (0.53) | TSHRLMNAABCC4MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023074639-A1 | POLYVINYL ALCOHOL FILM | 株式会社クラレ | 2023-05-04 | — | — | WO | disclosed |
| CN-110383124-A | Polarizing coating, polarizing film and their manufacturing method | 株式会社可乐丽 | 2019-10-25 | — | — | CN | disclosed |
| CN-110352369-A | Polarizing coating, polarizing film and their manufacturing method | 株式会社可乐丽 | 2019-10-18 | — | — | CN | disclosed |
| CN-110234666-A | Vinyl alcohol polymer and its manufacturing method containing pendant olefins | 株式会社可乐丽 | 2019-09-13 | — | — | CN | disclosed |
| CN-107000270-B | Polyvinyl alcohol film and its manufacturing method | 株式会社可乐丽 | 2019-08-13 | — | — | CN | disclosed |
| CN-104640912-B | polyvinyl alcohol film and polarizing film | 株式会社可乐丽 | 2019-07-26 | — | — | CN | disclosed |
| CN-109661442-A | COATING COMPOSITION FOR REPELLING AQUATIC ORGANISMS | 株式会社可乐丽 | 2019-04-19 | — | — | CN | disclosed |
| CN-105358602-B | modified resin and resin composition | 旭化成株式会社 | 2018-12-04 | — | — | CN | disclosed |
| CN-105518497-B | polarizing film | 株式会社可乐丽 | 2018-11-16 | — | — | CN | disclosed |
| CN-104185559-B | Hydraulic-transfer basement membrane | 株式会社可乐丽 | 2018-11-09 | — | — | CN | disclosed |
| CN-107001510-A | Vinyl alcohol polymer and use thereof | 株式会社可乐丽 | 2017-08-01 | — | — | CN | disclosed |
| CN-106927139-A | The package body of polyvinyl alcohol film volume | 株式会社可乐丽 | 2017-07-07 | — | — | CN | disclosed |
| CN-104024127-B | Package of polyvinyl alcohol film roll | 株式会社可乐丽 | 2017-06-20 | — | — | CN | disclosed |
| CN-106715492-A | Polyvinyl alcohol, and aqueous emulsion, adhesive, and emulsion polymerization dispersant comprising same | 株式会社可乐丽 | 2017-05-24 | — | — | CN | disclosed |
| CN-103467897-B | Polyvinyl acetal composition, laminate, and use thereof | 可乐丽股份有限公司 | 2017-04-12 | — | — | CN | disclosed |
| CN-106029755-A | Polyvinyl alcohol film and method for producing same | 株式会社可乐丽 | 2016-10-12 | — | — | CN | disclosed |
| CN-105940050-A | Polyvinyl alcohol film | 株式会社可乐丽 | 2016-09-14 | — | — | CN | disclosed |
| CN-105874364-A | Raw film for manufacturing optical films | 株式会社可乐丽 | 2016-08-17 | — | — | CN | disclosed |
| CN-105745563-A | Polarizing-film manufacturing method | 株式会社可乐丽 | 2016-07-06 | — | — | CN | disclosed |
| CN-105723259-A | Polyvinyl alcohol film | 株式会社可乐丽 | 2016-06-29 | — | — | CN | disclosed |