Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL6129933 | 0.84 | — | — | |
| Crotonic Acid SCHEMBL5796625 | 0.84 | TSHR (0.45) | TSHRTP53EGLN1EGLN3LMNA | |
| Crotonic Acid SCHEMBL27928983 | 0.84 | TSHR (0.45) | TSHRTP53EGLN1EGLN3LMNA | |
| Allyl Alcohol SCHEMBL465193 | 0.83 | — | — | |
| Allyl Alcohol SCHEMBL27117738 | 0.83 | TSHR (0.69) | TSHRLMNATDP1ABCC4MAPT | |
| Maleic Acid SCHEMBL27489187 | 0.81 | TSHR (0.56) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL27327513 | 0.81 | TSHR (0.56) | TSHRTP53EGLN1EGLN3LMNA | |
| Allyl Alcohol SCHEMBL27500481 | 0.79 | — | — | |
| Maleic Acid SCHEMBL16227722 | 0.79 | TSHR (0.57) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL865153 | 0.79 | LMNA (0.59) | TSHRTP53EGLN1EGLN3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014089001-A1 | POST-COATED CARBON ENHANCED REINFORCEMENT TOW AND CHOPPED STRANDS AND METHOD FOR FORMING SAME | OCV INTELLECTUAL CAPITAL, LLC (US) | 2014-06-12 | — | — | WO | claimed |
| EP-1223016-B1 | Chemical treatments for fibres and wire-coated composite strands for molding fiber-reinforced thermoplastic composite articles | OWENS CORNING FIBERGLASS CORP (US) | 2015-01-07 | — | — | EP | disclosed |
| EP-1223015-B1 | Chemical treatments for fibers and wire-coated composite strands for molding fiber-reinforced thermoplastic composite articles | OWENS CORNING FIBERGLASS CORP (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-0921919-B1 | CHEMICAL TREATMENTS FOR FIBERS AND WIRE-COATED COMPOSITE STRANDS FOR MOLDING FIBER-REINFORCED THERMOPLASTIC COMPOSITE ARTICLES | OWENS CORNING FIBERGLASS CORP (US) | 2005-07-13 | — | — | EP | disclosed |
| US-6533882-B1 | Chemical treatments for fibers and wire-coated composite strands for molding fiber-reinforced thermoplastic composite articles | OWENS CORNING FIBERGLAS TECHNOLOGY, INC. | 2003-03-18 | — | — | US | disclosed |
| EP-1223016-A2 | Chemical treatments for fibres and wire-coated composite strands for molding fiber-reinforced thermoplastic composite articles | OWENS CORNING (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1223015-A2 | Chemical treatments for fibers and wire-coated composite strands for molding fiber-reinforced thermoplastic composite articles | OWENS CORNING (US) | 2002-07-17 | — | — | EP | disclosed |
| US-6099910-A | APPLYING THERMOPLASTIC CHEMICAL TREATMENT FORMING A FILM AND COUPLING TO FIBERS | OWENS FIBERGLAS TECHNOLOGY, INC. (US) | 2000-08-08 | — | — | US | disclosed |
| US-5972503-A | A PREPREG STRAND COMPRISING A PLURALITY OF LINEAR AND ELECTRICAL NON-CONDUCTIVE REINFORCING FIBERS ENCASING TOGETHER WITH A SOLIDIFIED, SOLVENT-FREE FILM-FORMING POLYMER | OWENS CORNING FIBERGLAS TECHNOLOGY, INC. (US) | 1999-10-26 | — | — | US | disclosed |
| EP-0921919-A2 | CHEMICAL TREATMENTS FOR FIBERS AND WIRE-COATED COMPOSITE STRANDS FOR MOLDING FIBER-REINFORCED THERMOPLASTIC COMPOSITE ARTICLES | OWENS CORNING (US) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998006551-A2 | CHEMICAL TREATMENTS FOR FIBERS AND WIRE-COATED COMPOSITE STRANDS FOR MOLDING FIBER-REINFORCED THERMOPLASTIC COMPOSITE ARTICLES | OWENS CORNING (US) | 1998-02-19 | — | — | WO | disclosed |