Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | CPB1 | P15086 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MFN2 | O95140 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30645029 | 1.00 | ALDH1A1 (0.44) | ALDH1A1GAAKLK7CPB1PTGES | |
| SCHEMBL26112895 | 1.00 | ALDH1A1 (0.44) | ALDH1A1GAAKLK7CPB1PTGES | |
| SCHEMBL26112723 | 0.87 | MFN2 (0.46) | ALDH1A1GAACPB1MEN1KMT2A | |
| SCHEMBL26510111 | 0.87 | MFN2 (0.46) | ALDH1A1GAACPB1MEN1KMT2A | |
| SCHEMBL30645043 | 0.85 | MFN2 (0.49) | MEN1KMT2AMAPK1MFN2LMNA | |
| SCHEMBL26108764 | 0.85 | MFN2 (0.49) | MEN1KMT2AMAPK1MFN2LMNA | |
| SCHEMBL26108759 | 0.85 | MFN2 (0.49) | MEN1KMT2AMAPK1MFN2LMNA | |
| SCHEMBL25250950 | 0.80 | BCHE (0.46) | ALDH1A1GAACPB1MEN1KMT2A | |
| SCHEMBL31187934 | 0.77 | MFN2 (0.46) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL31470357 | 0.76 | CPB1 (0.57) | ALDH1A1GAACPB1TSHRTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250332124-A1 | MITOFUSIN ACTIVATORS HAVING AN ENDOCYCLIC-BONDED CARBONYL GROUP AND METHODS FOR USE THEREOF | DORN II GERALD W (US) | 2025-10-30 | — | — | US | disclosed |
| US-12396968-B2 | Mitofusin activators having an endocyclic-bonded carbonyl group and methods for use thereof | DORN II GERALD W (US) | 2025-08-26 | — | — | US | disclosed |
| US-20240050386-A1 | MITOFUSIN ACTIVATORS HAVING AN ENDOCYCLIC-BONDED CARBONYL GROUP AND METHODS FOR USE THEREOF | DORN II GERALD W (US) | 2024-02-15 | — | — | US | disclosed |
| WO-2023196340-A1 | MITOFUSIN ACTIVATORS HAVING AN ENDOCYCLIC-BONDED CARBONYL GROUP AND METHODS FOR USE THEREOF | DORN II GERALD W (US) | 2023-10-12 | — | — | WO | disclosed |
| WO-2023196340-A1 | MITOFUSIN ACTIVATORS HAVING AN ENDOCYCLIC-BONDED CARBONYL GROUP AND METHODS FOR USE THEREOF | DORN II GERALD W (US) | 2023-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12396968-B2 | Mitofusin activators having an endocyclic-bonded carbonyl group and methods for use thereof | MFN2, CYCS, CYC1 | ALDH1A1 4715/4885GAA 2958/4885KLK7 3657/4885 |
| US-20240050386-A1 | MITOFUSIN ACTIVATORS HAVING AN ENDOCYCLIC-BONDED CARBONYL GROUP AND METHODS FOR USE THEREOF | MFN2, CYCS, CYC1 | ALDH1A1 4715/4885GAA 2958/4885KLK7 3657/4885 |
| US-20250332124-A1 | MITOFUSIN ACTIVATORS HAVING AN ENDOCYCLIC-BONDED CARBONYL GROUP AND METHODS FOR USE THEREOF | MFN2, CYCS, CYC1 | ALDH1A1 4722/4885GAA 2941/4885KLK7 3622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.