Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997012 | 0.80 | MGAM (0.53) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL2506896 | 0.77 | MMP2 (0.40) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL11882511 | 0.73 | TDP1 (0.40) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL27915214 | 0.72 | GAA (0.63) | RAB9AMEN1KMT2ACYP3A4LMNA | |
| SCHEMBL25028187 | 0.71 | MMP2 (0.46) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL1199803 | 0.70 | L3MBTL1 (0.55) | L3MBTL1PAX8NPC1RAB9AMEN1 | |
| SCHEMBL16151139 | 0.69 | MMP2 (0.40) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL14740435 | 0.69 | MAPT (0.60) | ABL1NPC1RAB9APOLBMEN1 | |
| SCHEMBL2487170 | 0.68 | MAPT (0.41) | L3MBTL1NPC1RAB9APOLBMEN1 | |
| SCHEMBL25028313 | 0.67 | ILK (0.49) | CHEK1AURKADAPK3JAK2PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023187182-A1 | PYRAZOLOPYRAZINONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF | SANOFI (FR) | 2023-10-05 | — | — | WO | claimed |
| WO-2023187182-A1 | PYRAZOLOPYRAZINONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF | SANOFI (FR) | 2023-10-05 | — | — | WO | disclosed |