Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28052018 | 0.86 | MGLL (0.77) | MGLLMMP2MMP9MMP14ACHE | |
| SCHEMBL10812056 | 0.85 | KMT2A (0.63) | MGLLKMT2AMMP2MMP9MMP8 | |
| SCHEMBL13911210 | 0.83 | GAA (0.59) | MGLLKMT2AMMP2MMP9MMP8 | |
| SCHEMBL13944297 | 0.83 | KMT2A (0.54) | MGLLKMT2AMMP2MMP9MMP8 | |
| SCHEMBL1690926 | 0.83 | KMT2A (0.54) | MGLLKMT2AMMP2MMP9MMP8 | |
| SCHEMBL2453184 | 0.83 | KMT2A (0.54) | MGLLKMT2AMMP2MMP9MMP8 | |
| SCHEMBL25226904 | 0.81 | RAB9A (0.61) | MGLLKMT2AMMP2MMP9MMP8 | |
| SCHEMBL11341571 | 0.81 | MGLL (0.58) | MGLLKMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL13724309 | 0.81 | KMT2A (0.52) | MGLLKMT2AMMP2MMP9MMP8 | |
| SCHEMBL16918662 | 0.81 | FAAH (0.60) | MGLLKMT2AMMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023185864-A1 | Compounds for Targeted Degradation of KRAS | JINGRUI BIOPHARMA CO., LTD. (CN) | 2023-10-05 | — | — | WO | disclosed |
| CN-108136044-B | Imide-based proteolytic modulators and related methods of use | 阿尔维纳斯运营股份有限公司 | 2021-08-10 | — | — | CN | disclosed |
| CN-108136044-A | Imide-based proteolytic modulators and related methods of use | 阿尔维纳斯股份有限公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-102917590-B | Tricyclic compound and the PBK inhibitor containing described compound | ONCOTHERAPY SCIENCE, INC. (JP) | 2016-02-17 | — | — | CN | disclosed |