Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 11/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26145108 | 0.78 | GRIA2 (0.35) | GRIA4GRIA2 | |
| SCHEMBL26145147 | 0.71 | GRIA4 (0.32) | GRIA4GRIA2 | |
| SCHEMBL26145146 | 0.70 | GRIA2 (0.36) | GRIA4GRIA2 | |
| SCHEMBL22455852 | 0.69 | GRIA4 (0.33) | GRIA4GRIA2 | |
| SCHEMBL13450369 | 0.67 | CA12 (0.50) | GRIA4GRIA2 | |
| SCHEMBL15120964 | 0.66 | — | — | |
| SCHEMBL25847011 | 0.65 | — | — | |
| SCHEMBL21603620 | 0.65 | GRIA2 (0.35) | GRIA4GRIA2 | |
| SCHEMBL21374218 | 0.65 | — | — | |
| SCHEMBL22105485 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230147507-A1 | INDOLINE COMPOUNDS FOR INHIBITING KIF18A | VOLASTRA THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230147507-A1 | INDOLINE COMPOUNDS FOR INHIBITING KIF18A | KIF18A, KIF18B, KIF2C | GRIA4 3155/4885GRIA2 2528/4885GRIA1 2715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.