Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.47 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14278538 | 0.79 | ATM (0.46) | SMN1; SMN2ALDH1A1POLBTDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL11086720 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL13377027 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL21287457 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL12414740 | 0.74 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL6493190 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1POLBACHEMAPT | |
| SCHEMBL13360488 | 0.74 | POLB (0.48) | SMN1; SMN2ALDH1A1POLBHSD17B10ALOX15 | |
| SCHEMBL11193250 | 0.73 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1POLBKDM4EHSD17B10 | |
| SCHEMBL13377049 | 0.73 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL10239182 | 0.72 | POLB (0.52) | SMN1; SMN2ALDH1A1POLBHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101153-A1 | ROCAGLAOL DERIVATIVES AS CARDIOPROTECTANT AGENTS AND AS ANTINEOPLASTIC AGENTS | UNIVERSITE DE STRASBOURG (FR) | 2012-04-26 | — | — | US | disclosed |
| US-20120101153-A1 | ROCAGLAOL DERIVATIVES AS CARDIOPROTECTANT AGENTS AND AS ANTINEOPLASTIC AGENTS | UNIVERSITE DE STRASBOURG (FR) | 2012-04-26 | — | — | US | disclosed |
| WO-2010060891-A1 | ROCAGLAOL DERIVATIVES AS CARDIOPROTECTANT AGENTS AND AS ANTINEOPLASTIC AGENTS | UNIVERSITE DE STRASBOURG (FR) | 2010-06-03 | — | — | WO | disclosed |
| EP-2189453-A1 | Rocaglaol derivatives as cardioprotectant agents | Université Louis Pasteur (FR) | 2010-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101153-A1 | ROCAGLAOL DERIVATIVES AS CARDIOPROTECTANT AGENTS AND AS ANTINEOPLASTIC AGENTS | BAX, BAD, CASP3 | SMN1; SMN2 2156/4885ALDH1A1 468/4885POLB 4701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.