Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | CDC25B | P30305 | 3/20 | 0.34 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 5/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.32 |
| ▸ | PTPRF | P10586 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | CES1 | P23141 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31410969 | 0.80 | PTPRC (0.42) | CDC25BPTPRCMEN1KMT2AHSD17B10 | |
| SCHEMBL261676 | 0.76 | ABCG2 (0.62) | ABCG2MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL30019213 | 0.76 | ABCG2 (0.62) | ABCG2MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL7464999 | 0.74 | ABCG2 (0.55) | ABCG2CDC25BCDC25AMEN1KMT2A | |
| SCHEMBL2796799 | 0.72 | ABCG2 (0.37) | ABCG2 | |
| SCHEMBL29555333 | 0.70 | ABCG2 (0.37) | ABCG2CDC25BCDC25A | |
| SCHEMBL29555624 | 0.70 | PTPRC (0.42) | ABCG2PTPRCPTPN1MEN1KMT2A | |
| SCHEMBL7733305 | 0.69 | ABCG2 (0.50) | ABCG2HSD17B10ALDH1A1HPGDHIF1A | |
| SCHEMBL9118090 | 0.69 | ABCG2 (0.38) | ABCG2DRD2DRD4CDC25BCDC25A | |
| SCHEMBL3444897 | 0.68 | CDC25B (0.57) | CDC25BCDC25APTPRCPTPN1PTPRF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250074917-A1 | Preparation and Uses of 7-Azaindenoisoquinolines | PURDUE RESEARCH FOUNDATION | 2025-03-06 | — | — | US | disclosed |
| CN-119497715-A | Preparation and application of 7-aza-indeno isoquinoline | 珀杜研究基金会 | 2025-02-21 | — | — | CN | disclosed |
| US-9598418-B2 | Substituted phthalazin-1 (2H)-one derivatives as selective inhibitors of poly (ADP-ribose) polymerase-1 | CADILA HEALTHCARE LIMITED (IN) | 2017-03-21 | — | — | US | disclosed |
| EP-2938598-B1 | SUBSTITUTED PHTHALAZIN-1(2H)-ONE DERIVATIVES AS SELECTIVE INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE-1 | CADILA HEALTHCARE LTD (IN) | 2016-12-21 | — | — | EP | disclosed |
| US-20150291603-A1 | SUBSTITUTED PHTHALAZIN-1 (2H)-ONE DERIVATIVES AS SELECTIVE INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE-1 | CADILA HEALTHCARE LIMITED (IN) | 2015-10-15 | — | — | US | disclosed |
| EP-2598491-B1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1- CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE- 1 INHIBITORS | CADILA HEALTHCARE LTD (IN) | 2015-09-02 | — | — | EP | disclosed |
| US-8871765-B2 | Substituted 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one derivatives as poly (ADP-ribose) polymerase-1 inhibitors | CADILA HEALTHCARE LIMITED (IN) | 2014-10-28 | — | — | US | disclosed |
| EP-2598491-A1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1- CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE- 1 INHIBITORS | Cadila Healthcare Limited (IN) | 2013-06-05 | — | — | EP | disclosed |
| US-20130137695-A1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1-CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE-1 INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2013-05-30 | — | — | US | disclosed |
| WO-2012014221-A1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1- CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE- 1 INHIBITORS | CADILA HEALTHCARE LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |
| EP-1868607-A4 | ISOQUNOLINE COMPOUNDS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORP (US) | 2008-05-14 | — | — | EP | disclosed |
| EP-1868607-A2 | ISOQUNOLINE COMPOUNDS AND METHODS OF USE THEREOF | Inotek Pharmaceuticals Corporation (US) | 2007-12-26 | — | — | EP | disclosed |
| US-20060287313-A1 | Isoquinoline compounds and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2006-12-21 | — | — | US | disclosed |
| WO-2006093666-A2 | ISOQUNOLINE COMPOUNDS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250074917-A1 | Preparation and Uses of 7-Azaindenoisoquinolines | MYC, MYCBP, DNMT1 | ABCG2 1098/4885DRD2 3857/4885DRD4 2629/4885 |
| US-20130137695-A1 | SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1-CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE-1 INHIBITORS | PARP1, PARP2, PARP11 | ABCG2 766/4885DRD2 3800/4885DRD4 4006/4885 |
| US-20060287313-A1 | Isoquinoline compounds and methods of use thereof | GLS, PINK1, PARK7 | ABCG2 1512/4885DRD2 489/4885DRD4 670/4885 |
| US-20150291603-A1 | SUBSTITUTED PHTHALAZIN-1 (2H)-ONE DERIVATIVES AS SELECTIVE INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE-1 | PARP1, PARP11, PARP2 | ABCG2 58/4885DRD2 4523/4885DRD4 4409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.