SCHEMBL261678

SCHEMBL261678

[O-][S+](c1ncc[nH]1)c1ncc[nH]1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
NISCH Q9Y2I1 2/20 0.33
MTOR P42345 1/20 0.33
ADK P55263 1/20 0.33
MEN1 O00255 1/20 0.32
NPC1 O15118 1/20 0.32
HSP90AA1 P07900 1/20 0.32
AGTR1 P30556 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
ALOX15 P16050 1/20 0.31
TAAR1 Q96RJ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30864379 0.81 MTOR (0.42) ALDH1A1SMN1; SMN2NISCHMTORADK
SCHEMBL2947883 0.80
SCHEMBL3193203 0.80
SCHEMBL4685982 0.75
SCHEMBL12854154 0.75
SCHEMBL17368397 0.75 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2NISCHTAAR1
SCHEMBL22024413 0.75 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2NISCH
SCHEMBL4685983 0.75
SCHEMBL4685300 0.73 ALDH1A1 (0.37) ALDH1A1SMN1; SMN2TAAR1
SCHEMBL4684827 0.72 ALDH1A1 (0.31) ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 246 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118184644-A Polyol carbonate disulfate compound and preparation method thereof 联化科技(临海)有限公司 2024-06-14 CN claimed
CN-116813518-A Synthesis method of nemaltevir chiral intermediate 江苏暨明医药科技有限公司 2023-09-29 CN claimed
EP-2736909-B1 PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS FARMA GRS D O O (SI) 2017-03-29 EP claimed
EP-3109244-A2 PREPARATION OF 2'FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES Gilead Pharmasset LLC (US) 2016-12-28 EP claimed
US-20150218126-A1 CRYSTALLINE FORMS OF THALIDOMIDE AND PROCESSES FOR THEIR PREPARATION GENERICS [UK] LIMITED (GB) 2015-08-06 US claimed
EP-2121679-B1 METHOD FOR PRODUCING AZONIASPIRONORTROPINE ESTERS K H S PHARMA HOLDING GMBH (DE) 2015-04-15 EP claimed
EP-2736909-A1 PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS Farma GRS, d.o.o. (SI) 2014-06-04 EP claimed
EP-2079691-B1 SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOUR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS UNIV DUESSELDORF H HEINE (DE) 2013-08-14 EP claimed
US-20130143923-A1 CRYSTALLINE FORMS OF THALIDOMIDE AND PROCESSES FOR THEIR PREPARATION GENERICS [UK] LIMITED (GB) 2013-06-06 US claimed
CN-103068812-A Crystalline forms of thalidomide and processes for their preparation GENERICS UK LTD 2013-04-24 CN claimed
US-20050272934-A1 Process for the synthesis of thalidomide ANTIBIOTICOS S.P.A. (IT) 2005-12-08 US claimed
EP-1602654-A1 Process for the synthesis of thalidomide Antibioticos S.p.A. (IT) 2005-12-07 EP claimed
EP-0719280-B1 PROCESS FOR THE PREPARATION OF COMPOUNDS HAVING ACE INHIBITORY ACTION AS WELL AS NOVEL COMPOUNDS USEFUL AS STARTING MATERIALS OR INTERMEDIATES IN SAID PROCESS LEK TOVARNA FARMACEVTSKIH (SI) 1999-11-10 EP claimed
US-5789597-A ANGIOTENSIN CONVERTING ENZYME, ENALAPRIL MALEATE LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, D.D. (SI) 1998-08-04 US claimed
EP-0719280-A1 PROCESS FOR THE PREPARATION OF COMPOUNDS HAVING ACE INHIBITORY ACTION AS WELL AS NOVEL COMPOUNDS USEFUL AS STARTING MATERIALS OR INTERMEDIATES IN SAID PROCESS LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. (SI) 1996-07-03 EP claimed
WO-1996002564-A1 PROCESS FOR THE PREPARATION OF COMPOUNDS HAVING ACE INHIBITORY ACTION AS WELL AS NOVEL COMPOUNDS USEFUL AS STARTING MATERIALS OR INTERMEDIATES IN SAID PROCESS LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, D.D. (SI) 1996-02-01 WO claimed
EP-0257171-B1 (BENZOFURAN-2-YL)IMIDAZOLES HAVING PHARMACEUTICAL ACTIVITY, THEIR SALTS AND RELEVANT PRODUCTION PROCESSES A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1990-08-29 EP claimed
EP-0257171-A1 (Benzofuran-2-yl)imidazoles having pharmaceutical activity, their salts and relevant production processes A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1988-03-02 EP claimed
EP-0226320-A1 Imidazolyl thieno-benzothiepin derivatives and processes for the preparation thereof SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) 1987-06-24 EP claimed
US-4342754-A AND USE AS DIURETICS RICHTER GEDEON VEGYESZETI GYAR RT (HU) 1982-08-03 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130143923-A1 CRYSTALLINE FORMS OF THALIDOMIDE AND PROCESSES FOR THEIR PREPARATION TNF, UACA, VEGFA ALDH1A1 2821/4885SMN1; SMN2 4318/4885NISCH 1934/4885
US-20150218126-A1 CRYSTALLINE FORMS OF THALIDOMIDE AND PROCESSES FOR THEIR PREPARATION TNF, UACA, VEGFA ALDH1A1 2821/4885SMN1; SMN2 4318/4885NISCH 1934/4885
US-20050272934-A1 Process for the synthesis of thalidomide QPCT, GLUL, QPCTL ALDH1A1 2027/4885SMN1; SMN2 3534/4885NISCH 254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.