Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.58 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.58 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.54 |
| ▸ | RHEB | Q15382 | 1/20 | 0.49 |
| ▸ | LATS1 | O95835 | 1/20 | 0.48 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 6/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 3/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719855 | 0.81 | RHEB (0.47) | TGFBR1IKBKEPDPK1TBK1RHEB | |
| SCHEMBL30874496 | 0.76 | CDK1 (0.71) | PDPK1RPS6KA5CDK2KDM4ENPC1 | |
| SCHEMBL29714866 | 0.76 | CLK2 (0.50) | TGFBR1PDPK1DYRK1AKDM4ECLK2 | |
| SCHEMBL17555908 | 0.76 | CLK2 (0.50) | TGFBR1PDPK1DYRK1AKDM4ECLK2 | |
| SCHEMBL8566063 | 0.74 | ALDH1A1 (0.50) | CDK2CDK5CDK5R1GSK3BKDM4E | |
| SCHEMBL12501045 | 0.74 | TGFBR1 (1.00) | TGFBR1IKBKEPDPK1TBK1RPS6KA5 | |
| SCHEMBL5618155 | 0.74 | TGFBR1 (0.71) | TGFBR1IKBKEPDPK1TBK1RPS6KA5 | |
| SCHEMBL16572576 | 0.73 | TGFBR1 (0.67) | TGFBR1IKBKEPDPK1TBK1LATS1 | |
| SCHEMBL20466101 | 0.72 | METAP2 (0.50) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL857678 | 0.71 | IKBKE (0.64) | TGFBR1IKBKEPDPK1TBK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | TENARX, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | TENARX, INC. | 2023-06-22 | — | — | US | disclosed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | DYRK1A, DYRK1B, DYRK2 | TGFBR1 2134/4885IKBKE 746/4885PDPK1 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.