SCHEMBL26180175

SCHEMBL26180175

COCC(COC)Nc1ncc(-c2n[nH]c3c(C#N)cccc23)nc1C

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 3/20 0.32
▸ LRRK2 Q5S007 2/20 0.31
▸ SOS1 Q07889 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29364153 0.83 GSK3B (0.46) LRRK2SOS1
SCHEMBL25029067 0.83 GSK3B (0.46) LRRK2SOS1
SCHEMBL25029318 0.77 NFATC1 (0.32) LRRK2
SCHEMBL26180177 0.76 IRAK4 (0.43) —
SCHEMBL25218789 0.74 NFATC1 (0.32) —
SCHEMBL29364692 0.74 NFATC1 (0.32) —
SCHEMBL25029103 0.73 MBOAT4 (0.36) LRRK2
SCHEMBL29364371 0.73 MBOAT4 (0.36) LRRK2
SCHEMBL26180189 0.73 AAK1 (0.35) LRRK2
SCHEMBL26180157 0.72 GSK3B (0.41) LRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11667624-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2023-06-06 — — US disclosed
US-11667624-B2 Indole compounds as androgen receptor modulators NIDO BIOSCIENCES, INC. (US) 2023-06-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11667624-B2 Indole compounds as androgen receptor modulators AR, FSHR, ADRB3 MAPK1 3135/4885LRRK2 199/4885SOS1 4568/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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