Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12330773 | 0.88 | CDK8 (0.51) | MAPTHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL31483499 | 0.86 | ALDH1A1 (0.52) | BCL2BECN1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL19853243 | 0.85 | MTNR1B (0.58) | ALDH1A1POLBSMN1; SMN2RAB9AHPGD | |
| SCHEMBL10269469 | 0.85 | CA1 (0.45) | MAPTHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL10269053 | 0.85 | MITF (0.44) | MAPTHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL29730783 | 0.83 | RAB9A (0.48) | MAPTHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL29895464 | 0.82 | GAA (0.55) | MAPTHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL1400198 | 0.82 | GAA (0.55) | MAPTHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL25128584 | 0.81 | HDAC3 (0.48) | MAPTHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL20995657 | 0.80 | ALDH1A1 (0.56) | MAPTHDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3481831-B1 | 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINYLAZABICYCLO DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO LTD (KR) | 2023-09-06 | — | — | EP | disclosed |