SCHEMBL26201216

SCHEMBL26201216

Cc1cc(C)c(-c2c(-c3c(C)cc(OI)cc3C)c2=O)c(C)c1

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GRIN2D O15399 1/20 0.31
GRIN3B O60391 1/20 0.31
GRIN1 Q05586 1/20 0.31
GRIN2A Q12879 1/20 0.31
GRIN2B Q13224 1/20 0.31
GRIN2C Q14957 1/20 0.31
GRIN3A Q8TCU5 1/20 0.31
HSD17B10 Q99714 1/20 0.31
TSHR P16473 1/20 0.30
ADORA3 P0DMS8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26200975 0.82 GRIN2D (0.39) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL26201031 0.82 ALDH1A1 (0.42)
SCHEMBL26201170 0.80 ABCB1 (0.31) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL26201092 0.74 ELANE (0.49) HSD17B10TSHR
SCHEMBL26200999 0.73 THRA (0.43) TSHR
SCHEMBL26201035 0.72 ALDH1A1 (0.46) HSD17B10TSHR
SCHEMBL26201033 0.72 ACHE (0.45)
SCHEMBL26201178 0.72 ELANE (0.35) TSHR
SCHEMBL26201039 0.71 PIM1 (0.47) HSD17B10TSHR
SCHEMBL26200980 0.71 MAPT (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230280275-A1 PHOTOACTIVATABLE VIBRATIONAL PROBES AND USES THEREOF CALIFORNIA INSTITUTE OF TECHNOLOGY 2023-09-07 US disclosed