Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26205908 | 0.92 | MEN1 (0.48) | MEN1KMT2AALDH1A1KDM4EHSP90AA1 | |
| SCHEMBL26205834 | 0.90 | KMT2A (0.54) | MEN1KMT2AALDH1A1KDM4EMGLL | |
| SCHEMBL26205906 | 0.89 | KMT2A (0.45) | MEN1KMT2AALDH1A1KDM4EMGLL | |
| SCHEMBL26205855 | 0.89 | MEN1 (0.52) | MEN1KMT2AALDH1A1KDM4EMGLL | |
| SCHEMBL24437413 | 0.89 | MEN1 (0.51) | MEN1KMT2AALDH1A1KDM4EHSP90AA1 | |
| SCHEMBL26205910 | 0.88 | MGLL (0.46) | MEN1KMT2AALDH1A1KDM4EHSP90AA1 | |
| SCHEMBL26205826 | 0.87 | MEN1 (0.52) | MEN1KMT2AALDH1A1KDM4EHSP90AA1 | |
| SCHEMBL26205811 | 0.87 | KMT2A (0.50) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL26205886 | 0.87 | KMT2A (0.50) | MEN1KMT2AALDH1A1KDM4EHSP90AA1 | |
| SCHEMBL26205843 | 0.87 | MEN1 (0.68) | MEN1KMT2AALDH1A1KDM4EMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753374-B2 | Compounds for the treatment of acute and chronic kidney disease | Southern Reserach Institute (US) | 2023-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753374-B2 | Compounds for the treatment of acute and chronic kidney disease | HMOX1, GLS, HMOX2 | MEN1 4171/4885KMT2A 2088/4885ALDH1A1 703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.