Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.45 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL261232 | 0.86 | KIF11 (0.64) | KIF11ALDH1A1MAPTKMT2AGAA | |
| SCHEMBL10683046 | 0.80 | SMN1; SMN2 (0.56) | ALDH1A1TSHRHSD17B10MAPTKMT2A | |
| SCHEMBL4348957 | 0.80 | KIF11 (0.59) | KIF11ALDH1A1TP53TYRTSHR | |
| SCHEMBL3497043 | 0.77 | MAPT (0.52) | ALDH1A1TSHRMAPTKMT2ACYP2D6 | |
| SCHEMBL12071196 | 0.76 | CYP17A1 (0.51) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL12070405 | 0.75 | ALDH1A1 (0.64) | KIF11ALDH1A1TP53TYRTSHR | |
| SCHEMBL725810 | 0.74 | ALDH1A1 (0.75) | KIF11ALDH1A1TP53TYRTSHR | |
| SCHEMBL23987221 | 0.74 | KIF11 (0.53) | KIF11ALDH1A1TP53TYRTSHR | |
| SCHEMBL5458028 | 0.74 | SMN1; SMN2 (0.61) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL27477483 | 0.73 | KIF11 (0.42) | KIF11ALDH1A1TP53TYRTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346841-B1 | 2-ARYL-PROPIONIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPÉ S P A (IT) | 2015-01-14 | — | — | EP | claimed |
| US-8133911-B2 | (R)-4-(heteroaryl) phenylethyl derivatives and pharmaceutical compositions containing them | DOMPE S.P.A (IT) | 2012-03-13 | — | — | US | disclosed |
| EP-2201006-B1 | (R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE SPA (IT) | 2011-03-09 | — | — | EP | disclosed |