Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 10/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26215211 | 0.85 | MAPT (0.48) | MEN1KMT2ACXCR1MAPTSMN1; SMN2 | |
| SCHEMBL16549592 | 0.80 | RAB9A (0.54) | MEN1KMT2ACXCR1MAPTSMN1; SMN2 | |
| SCHEMBL19403807 | 0.78 | CXCR1 (0.50) | MEN1KMT2ACXCR1MAPTSMN1; SMN2 | |
| SCHEMBL3226277 | 0.77 | MEN1 (0.71) | MEN1KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL12203569 | 0.77 | MEN1 (0.71) | MEN1KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL3459689 | 0.76 | CXCR1 (0.49) | MEN1KMT2ACXCR1MAPTSMN1; SMN2 | |
| SCHEMBL24168672 | 0.76 | MEN1 (0.69) | MEN1KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL19625484 | 0.76 | MEN1 (0.69) | MEN1KMT2ACXCR1MAPTSMN1; SMN2 | |
| SCHEMBL26262561 | 0.76 | MEN1 (0.69) | MEN1KMT2ACXCR1MAPTSMN1; SMN2 | |
| SCHEMBL3715675 | 0.75 | ALDH1A1 (0.43) | MEN1KMT2ACXCR1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230286904-A1 | INHIBITORS OF YAP/TAZ-TEAD ONCOPROTEINS, SYNTHESIS AND USE THEREOF | BRIDGENE BIOSCIENCES, INC. | 2023-09-14 | — | — | US | disclosed |
| CN-116490201-A | Inhibitors of YAP/TAZ-TEAD tumor proteins, their synthesis and use | 布里奇恩生物科学公司 | 2023-07-25 | — | — | CN | disclosed |
| EP-4175658-A1 | INHIBITORS OF YAP/TAZ-TEAD ONCOPROTEINS, SYNTHESIS AND USE THEREOF | Bridgene Biosciences, Inc. (US) | 2023-05-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230286904-A1 | INHIBITORS OF YAP/TAZ-TEAD ONCOPROTEINS, SYNTHESIS AND USE THEREOF | TEAD1, TEAD2, TEAD3 | MEN1 624/4885KMT2A 825/4885CXCR1 3183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.