Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EBP | Q15125 | 1/20 | 0.37 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21613806 | 0.90 | DHCR7 (0.50) | NPC1RAB9AALDH1A1LMNAHPGD | |
| SCHEMBL13818482 | 0.89 | RAB9A (0.42) | NPC1RAB9AALDH1A1LMNAHPGD | |
| SCHEMBL21613729 | 0.86 | DHCR7 (0.56) | NPC1RAB9AALDH1A1LMNAHPGD | |
| SCHEMBL23844179 | 0.80 | HRH3 (0.44) | NPC1RAB9AALDH1A1LMNAHPGD | |
| SCHEMBL23178944 | 0.80 | HPGD (0.46) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL18583232 | 0.79 | HPGD (0.43) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL21613881 | 0.78 | SMN1; SMN2 (0.33) | NPC1RAB9AALDH1A1LMNAHPGD | |
| SCHEMBL4521726 | 0.77 | SMN1; SMN2 (0.39) | NPC1RAB9AALDH1A1LMNAHPGD | |
| SCHEMBL27377328 | 0.76 | OPRM1 (0.43) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL21613791 | 0.75 | LMNA (0.41) | NPC1RAB9AALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262036-B1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2023-09-13 | — | — | EP | disclosed |