Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9175696 | 0.87 | P2RX7 (0.33) | P2RX7APLNRCTSLMEN1MAPK1 | |
| SCHEMBL8568717 | 0.86 | APLNR (0.34) | P2RX7APLNRCTSLMEN1MAPK1 | |
| SCHEMBL3880022 | 0.84 | P2RX7 (0.31) | P2RX7 | |
| SCHEMBL4726064 | 0.84 | P2RX7 (0.34) | P2RX7APLNRCTSLMEN1MAPK1 | |
| SCHEMBL3942864 | 0.84 | P2RX7 (0.34) | P2RX7APLNRCTSLMEN1MAPK1 | |
| SCHEMBL13738955 | 0.84 | P2RX7 (0.34) | P2RX7APLNRCTSLMEN1MAPK1 | |
| SCHEMBL13738101 | 0.84 | P2RX7 (0.34) | P2RX7APLNRCTSLMEN1MAPK1 | |
| SCHEMBL16993451 | 0.82 | TDP1 (0.36) | P2RX7APLNRCTSLMEN1MAPK1 | |
| SCHEMBL18530347 | 0.82 | TDP1 (0.36) | P2RX7APLNRCTSLMEN1MAPK1 | |
| SCHEMBL14813442 | 0.82 | CA12 (0.33) | P2RX7APLNRCTSLMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3654968-B1 | METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC (US) | 2023-08-16 | — | — | EP | disclosed |