Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 3/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704422 | 0.82 | KDM4E (0.46) | KDM4EHSD17B10KMT2AMEN1PDE2A | |
| SCHEMBL8367026 | 0.82 | CYP11B1 (0.46) | MCHR1RAB9ANPC1ACSS2CSNK2A2 | |
| SCHEMBL2625553 | 0.81 | KDM4E (0.45) | MCHR1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL7996781 | 0.77 | LMNA (0.57) | KDM4EHSD17B10KMT2AMEN1GAA | |
| SCHEMBL23105625 | 0.76 | KMT2A (0.45) | KDM4EHSD17B10KMT2AMEN1PDE2A | |
| SCHEMBL12827141 | 0.75 | HDAC6 (0.50) | MCHR1KDM4EKMT2AMEN1GAA | |
| SCHEMBL1104857 | 0.74 | KDM4E (0.58) | KDM4EKMT2AMEN1PDE2APDE3B | |
| SCHEMBL24329592 | 0.74 | MEN1 (0.51) | KDM4EHSD17B10KMT2AMEN1PDE2A | |
| SCHEMBL25080567 | 0.72 | NPC1 (0.41) | MCHR1KDM4EHSD17B10KMT2AMEN1 | |
| SCHEMBL5226280 | 0.72 | KDM4E (0.44) | KDM4EHSD17B10HPGDGFERNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |