Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2625546 | 0.82 | MCHR1 (0.43) | KDM4EHSD17B10PDE2APDE3BPDE3A | |
| SCHEMBL1104857 | 0.80 | KDM4E (0.58) | KDM4EPDE2APDE3BPDE3ARAB9A | |
| SCHEMBL24329592 | 0.80 | MEN1 (0.51) | KDM4EHSD17B10PDE2APDE3BPDE3A | |
| SCHEMBL28053815 | 0.77 | TLR8 (0.43) | KDM4EPDE2APDE3BPDE3AGAA | |
| SCHEMBL1704421 | 0.77 | TLR8 (0.58) | KDM4EPDE2APDE3BPDE3AGAA | |
| SCHEMBL23638274 | 0.77 | TLR8 (0.43) | KDM4EHSD17B10PDE2APDE3BPDE3A | |
| SCHEMBL29468491 | 0.77 | TLR8 (0.43) | KDM4EPDE2APDE3BPDE3AGAA | |
| SCHEMBL979518 | 0.77 | TLR8 (0.58) | KDM4EPDE2APDE3BPDE3AGAA | |
| SCHEMBL1707296 | 0.74 | ALDH1A1 (0.58) | KDM4EHSD17B10HPGDALDH1A1MAPT | |
| SCHEMBL978780 | 0.74 | ALDH1A1 (0.58) | KDM4EHSD17B10HPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440294-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010144680-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TRPM8 CHANNEL MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-16 | — | — | WO | disclosed |