Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 9/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 9/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2626812 | 0.88 | ADRA2A (0.44) | CYP19A1ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL2626795 | 0.80 | ADRA2A (0.63) | CYP19A1ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL2626829 | 0.79 | ADRA2A (0.68) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL2626798 | 0.79 | CYP19A1 (0.52) | CYP19A1ADRA2AADRA2BADRA2CTAAR1 | |
| SCHEMBL8820677 | 0.78 | HRH3 (0.53) | CYP19A1TAAR1CPA1 | |
| SCHEMBL21401161 | 0.78 | ADRA2A (0.62) | CYP19A1ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL21910179 | 0.76 | IDO1 (0.47) | CYP3A4CYP2C9TSHRTAAR1 | |
| Ammonia Solution, Strong SCHEMBL6001393 | 0.74 | IDO1 (0.46) | CYP19A1CYP3A4CYP2C9TSHR | |
| SCHEMBL2626800 | 0.74 | CYP19A1 (0.59) | CYP19A1ADRA2ATAAR1 | |
| SCHEMBL23159325 | 0.73 | HRH1 (0.50) | CYP19A1CYP1A2CYP3A4CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158668-B2 | Methods for treating CNS disorders with 4-imidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-8158668-B2 | Methods for treating CNS disorders with 4-imidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-20070197622-A1 | Methods for treating CNS disorders with 4-imidazole derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-08-23 | — | — | US | disclosed |
| US-20070197622-A1 | Methods for treating CNS disorders with 4-imidazole derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-08-23 | — | — | US | disclosed |
| WO-2007085556-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197622-A1 | Methods for treating CNS disorders with 4-imidazole derivatives | CRY1, GPR119, MTNR1A | CYP19A1 192/4885ADRA2A 116/4885ADRA2B 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.