Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 2/20 | 0.61 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1986953 | 1.00 | GABBR2 (0.61) | GABBR2GABBR1TAAR1HTR2ASLC6A2 | |
| SCHEMBL9787802 | 1.00 | GABBR2 (0.61) | GABBR2GABBR1TAAR1HTR2ASLC6A2 | |
| Hydrochloric Acid SCHEMBL14764043 | 0.98 | GABBR2 (0.59) | GABBR2GABBR1TAAR1HTR2ASLC6A2 | |
| SCHEMBL1539105 | 0.85 | TAAR1 (0.65) | GABBR2GABBR1TAAR1HTR2ASLC6A2 | |
| SCHEMBL148756 | 0.85 | TRPA1 (0.48) | GABBR2GABBR1TAAR1HTR2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL10676327 | 0.82 | TAAR1 (0.62) | GABBR2GABBR1TAAR1HTR2ASLC6A2 | |
| SCHEMBL2628024 | 0.82 | GABBR2 (0.57) | GABBR2GABBR1TAAR1HTR2ASLC6A2 | |
| SCHEMBL7899168 | 0.82 | HRH1 (0.58) | GABBR2GABBR1TAAR1HTR2ASLC6A2 | |
| SCHEMBL3662680 | 0.82 | HRH1 (0.58) | GABBR2GABBR1TAAR1HTR2ASLC6A2 | |
| Hydrochloric Acid SCHEMBL8987516 | 0.80 | HRH1 (0.56) | GABBR2GABBR1TAAR1HTR2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |
| EP-2766352-A1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | University Health Network (UHN) (CA) | 2014-08-20 | — | — | EP | disclosed |
| WO-2013053051-A1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2013-04-18 | — | — | WO | disclosed |
| WO-2008156654-A2 | CYTOSKELETON MODULATORS FOR TREATING METABOLIC DISORDERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-12-24 | — | — | WO | disclosed |