Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 12/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.39 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.39 |
| ▸ | GGT1 | P19440 | 1/20 | 0.37 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CTH | P32929 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9716637 | 0.89 | FOLH1 (0.51) | FOLH1TGFBR1SLC6A5 | |
| SCHEMBL9716635 | 0.89 | FOLH1 (0.51) | FOLH1TGFBR1SLC6A5 | |
| SCHEMBL9716631 | 0.89 | FOLH1 (0.51) | FOLH1TGFBR1SLC6A5 | |
| SCHEMBL9698704 | 0.87 | FOLH1 (0.58) | FOLH1SLC6A5 | |
| SCHEMBL3435138 | 0.87 | FOLH1 (0.58) | FOLH1SLC6A5 | |
| Hydrochloric Acid SCHEMBL31741284 | 0.85 | FOLH1 (0.57) | FOLH1SLC6A5 | |
| SCHEMBL14932839 | 0.84 | GABRR1 (0.34) | GABRR1ALOX15 | |
| SCHEMBL14302360 | 0.83 | TGFBR1 (0.42) | FOLH1TGFBR1NAALAD2KDM4EMAPT | |
| SCHEMBL303956 | 0.82 | CTSK (0.49) | — | |
| SCHEMBL2612149 | 0.82 | CTSK (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245027-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010132601-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |