Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16455450 | 0.92 | ELANE (0.56) | ELANECYP2C9CYP3A4 | |
| SCHEMBL15473015 | 0.88 | ELANE (0.50) | ELANECYP2C9 | |
| SCHEMBL16455442 | 0.88 | ELANE (0.50) | ELANECYP2C9 | |
| SCHEMBL15473019 | 0.88 | ELANE (0.49) | ELANECYP2C9 | |
| SCHEMBL2631476 | 0.87 | ELANE (0.58) | ELANECYP2C9CYP3A4 | |
| SCHEMBL123237 | 0.85 | ELANE (0.78) | ELANECYP2C9CYP3A4 | |
| SCHEMBL2630695 | 0.85 | ELANE (0.57) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5955575 | 0.84 | ELANE (0.71) | ELANECYP2C9CYP3A4 | |
| SCHEMBL15473116 | 0.84 | ELANE (0.55) | ELANECYP2C9CYP3A4 | |
| SCHEMBL2631132 | 0.84 | ELANE (0.63) | ELANECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174997-B2 | 4-(4-cyano-2-thioaryl)dihydropyrimidinones and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-20150045344-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF | PH PHARMA CO., LTD. (KR) | 2015-02-12 | — | — | US | disclosed |
| US-8691817-B2 | Sulfonic amide and sulfoximine-substituted diaryl-dihydropyrimidinones and usage thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-04-08 | — | — | US | disclosed |
| US-20120094968-A1 | SULFONIC AMIDE AND SULFOXIMINE-SUBSTTTUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094968-A1 | SULFONIC AMIDE AND SULFOXIMINE-SUBSTTTUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF | STS, SQOR, TST | ELANE 2343/4885CYP2C9 2026/4885CYP3A4 1774/4885 |
| US-20150045344-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF | TNNI3, TNNT2, PC | ELANE 1850/4885CYP2C9 581/4885CYP3A4 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.