Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14453332 | 0.90 | HPGD (0.61) | HPGDMAPK1MEN1KMT2ALMNA | |
| SCHEMBL5177018 | 0.88 | HPGD (0.58) | HPGDMAPK1MEN1KMT2ALMNA | |
| SCHEMBL28916549 | 0.81 | HPGD (0.69) | HPGDMAPK1MEN1KMT2ALMNA | |
| SCHEMBL29209373 | 0.80 | ALDH1A1 (0.49) | HPGDMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL3456729 | 0.80 | HPGD (0.96) | HPGDMAPK1MEN1KMT2ALMNA | |
| SCHEMBL3454812 | 0.80 | HPGD (0.96) | HPGDMAPK1MEN1KMT2ALMNA | |
| SCHEMBL29209339 | 0.78 | ALOX5 (0.50) | HPGDMAPK1MEN1KMT2ALMNA | |
| SCHEMBL29209387 | 0.78 | CHRNA7 (0.48) | HPGDMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL29209375 | 0.78 | RAB9A (0.50) | HPGDMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6614562 | 0.78 | HPGD (1.00) | HPGDMAPK1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101129-A1 | Methylphenidate Derivatives and Uses of Them | AMPIO PHARMACEUTICALS, INC. | 2012-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101129-A1 | Methylphenidate Derivatives and Uses of Them | SLC6A3, COMT, UGT1A1 | HPGD 2196/4885MAPK1 2209/4885MEN1 2866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.