Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.54 |
| ▸ | KCND2 | Q9NZV8 | 5/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1762230 | 0.98 | KCNA5 (0.56) | SLC6A4KCNA5SCN5AKCND2KCNH2 | |
| SCHEMBL15171306 | 0.90 | CALM1 (0.53) | SLC6A4KCNA5SCN5AKCND2KCNH2 | |
| SCHEMBL15171307 | 0.90 | SLC6A4 (0.47) | SLC6A4KCNA5SCN5AKCND2KCNH2 | |
| SCHEMBL12945065 | 0.88 | SLC6A4 (0.47) | SLC6A4KCNA5SCN5AKCND2KCNH2 | |
| SCHEMBL15171305 | 0.87 | TAAR1 (0.55) | SLC6A4PDE4B | |
| SCHEMBL2960049 | 0.83 | SLC6A4 (0.51) | SLC6A4KCNA5SCN5AKCND2KCNH2 | |
| SCHEMBL12122823 | 0.81 | SLC6A4 (0.61) | SLC6A4KCNA5SCN5AKCND2KCNH2 | |
| SCHEMBL14886381 | 0.81 | SLC6A4 (0.61) | SLC6A4KCNA5SCN5AKCND2KCNH2 | |
| SCHEMBL12122818 | 0.81 | SLC6A4 (0.61) | SLC6A4KCNA5SCN5AKCND2KCNH2 | |
| SCHEMBL14390513 | 0.81 | SLC6A4 (0.61) | SLC6A4KCNA5SCN5AKCND2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586899-B2 | Synthetic process for aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2017-03-07 | — | — | US | disclosed |
| US-20150336887-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | CORREVIO CANADA CORP. (CA) | 2015-11-26 | — | — | US | disclosed |
| EP-1915340-B1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP (CA) | 2013-08-07 | — | — | EP | disclosed |
| US-20130102791-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2013-04-25 | — | — | US | disclosed |
| US-8163938-B2 | Aminocyclohexyl ether compounds and uses thereof | CARDIOME PHARMA CORP. (CA) | 2012-04-24 | — | — | US | disclosed |
| WO-2012024100-A2 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |
| EP-1666459-B1 | Aminocyclohexyl ether compounds and uses thereof | CARDIOME PHARMA CORP (CA) | 2011-10-19 | — | — | EP | disclosed |
| EP-2298735-A1 | Aminocyclohexyl ether compounds and uses thereof | Cardiome Pharma Corp. (CA) | 2011-03-23 | — | — | EP | disclosed |
| US-20110004006-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2011-01-06 | — | — | US | disclosed |
| US-7767830-B2 | Aminocyclohexyl ether compounds and uses thereof | CARDIOME PHARMA CORP. (CA) | 2010-08-03 | — | — | US | disclosed |
| US-20100152464-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2010-06-17 | — | — | US | disclosed |
| US-20090105256-A1 | PRODRUGS OF ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2009-04-23 | — | — | US | disclosed |
| US-20070254945-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2007-11-01 | — | — | US | disclosed |
| US-20070099983-A1 | Aminocyclohexyl ether compounds and uses thereof | CARDIOME PHARMA CORP. (CA) | 2007-05-03 | — | — | US | disclosed |
| WO-2005097203-A2 | SERUM PROTEIN CONJUGATES OF ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2005-10-20 | — | — | WO | disclosed |
| WO-2005016242-A2 | SYNTHETIC PROCESS FOR TRANS-AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2005-02-24 | — | — | WO | disclosed |
| WO-2004098525-A2 | USES OF ION CHANNEL MODULATING COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110004006-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | KCNH2, KCNC1, KCNH3 | SLC6A4 1837/4885KCNA5 16/4885SCN5A 24/4885 |
| US-20130102791-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | DDC, PAICS, CYP4F2 | SLC6A4 2113/4885KCNA5 3600/4885SCN5A 3852/4885 |
| US-20070254945-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | KCNH2, KCNC1, KCNH3 | SLC6A4 1837/4885KCNA5 16/4885SCN5A 24/4885 |
| US-20090105256-A1 | PRODRUGS OF ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CACNA1B, CACNA1F, KCNN2 | SLC6A4 231/4885KCNA5 48/4885SCN5A 37/4885 |
| US-20150336887-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | DDC, PAICS, CYP4F2 | SLC6A4 2113/4885KCNA5 3600/4885SCN5A 3852/4885 |
| US-20070099983-A1 | Aminocyclohexyl ether compounds and uses thereof | KCNH2, KCNC1, KCNH3 | SLC6A4 1837/4885KCNA5 16/4885SCN5A 24/4885 |
| US-20100152464-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | DDC, PAICS, CYP4F2 | SLC6A4 2113/4885KCNA5 3600/4885SCN5A 3852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.