SCHEMBL26327166

SCHEMBL26327166

CC[C@H]1C[C@@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ AHCY P23526 1/20 0.43
▸ PRMT6 Q96LA8 1/20 0.40
▸ P2RY12 Q9H244 2/20 0.40
▸ P2RY2 P41231 1/20 0.40
▸ P2RY1 P47900 1/20 0.40
▸ P2RY6 Q15077 1/20 0.40
▸ BMPR1B O00238 1/20 0.39
▸ ADORA1 P30542 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25496037 1.00 AHCY (0.43) AHCYPRMT6P2RY12P2RY2P2RY1
SCHEMBL26533861 0.92 PRMT6 (0.40) AHCYPRMT6P2RY12BMPR1B
SCHEMBL25495950 0.87 PRMT5 (0.38) —
SCHEMBL25496131 0.87 PRMT5 (0.38) —
SCHEMBL26533859 0.87 PRMT6 (0.40) PRMT6P2RY12ADORA1
SCHEMBL20337209 0.86 TYMP (0.43) P2RY12P2RY2P2RY1P2RY6ADORA1
SCHEMBL20353032 0.86 TYMP (0.43) P2RY12P2RY2P2RY1P2RY6ADORA1
SCHEMBL26327164 0.86 AHCY (0.59) AHCY
SCHEMBL25496027 0.86 AHCY (0.59) AHCY
SCHEMBL20337202 0.84 PRMT6 (0.39) PRMT6P2RY12ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11787833-B2 Modified cyclic dinucleoside compounds as sting modulators ALIGOS THERAPEUTICS, INC. (US) 2023-10-17 — — US disclosed
US-11766447-B2 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) 2023-09-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11766447-B2 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator STING1, MAVS, CGAS AHCY 1261/4885PRMT6 1569/4885P2RY12 434/4885
US-11787833-B2 Modified cyclic dinucleoside compounds as sting modulators STING1, CGAS, IRF3 AHCY 4633/4885PRMT6 1677/4885P2RY12 366/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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