Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13537499 | 0.82 | NOTUM (0.44) | MAPTTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29119447 | 0.81 | HSP90AA1 (0.48) | ALDH1A1MAPTGAAMEN1KMT2A | |
| SCHEMBL31577274 | 0.81 | ALOX5 (0.72) | ALOX5EPHX2KCNT1 | |
| SCHEMBL2625806 | 0.81 | NPC1 (0.61) | ALDH1A1MAPTTP53GAAMEN1 | |
| SCHEMBL11813937 | 0.81 | RAB9A (0.53) | ALDH1A1MAPTTP53MEN1KMT2A | |
| SCHEMBL12381933 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MAPTTP53GAAMEN1 | |
| SCHEMBL15601456 | 0.80 | ALOX5 (0.56) | MEN1KMT2ANPC1RAB9AALOX5 | |
| SCHEMBL15524920 | 0.80 | ALOX5 (0.70) | ALDH1A1ALOX5EPHX2KCNT1 | |
| SCHEMBL11682254 | 0.79 | SMN1; SMN2 (0.70) | ALDH1A1MAPTTP53NPC1RAB9A | |
| SCHEMBL15524919 | 0.79 | ALOX5 (0.58) | ALDH1A1MEN1KMT2AALOX5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163720-B2 | Pyrrolidinyl phenyl sulphonamides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2308872-A1 | Heterocyclic derivatives as modulators of ion channels | Vertex Pharmaceuticals Incorporated (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2007075895-A2 | HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-05 | — | — | WO | disclosed |