Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2632813 | 0.81 | ALDH1A1 (0.52) | HSP90AA1TLR9BAZ2BRAB9ANPC1 | |
| SCHEMBL29119496 | 0.80 | MLNR (0.51) | ACLYCYP1A2ADRA2AMAOASLC6A2 | |
| SCHEMBL4591071 | 0.76 | NPC1 (0.53) | HSP90AA1TLR9ACLYCYP1A2ADRA2A | |
| SCHEMBL29860127 | 0.75 | ATAD2 (0.49) | HTR1AHTR2ARAB9ANPC1KDM4E | |
| SCHEMBL29119500 | 0.75 | ATAD2 (0.49) | HTR1AHTR2ARAB9ANPC1KDM4E | |
| SCHEMBL29119509 | 0.75 | TP53 (0.42) | HSP90AA1KDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL11813937 | 0.74 | RAB9A (0.53) | BAZ2BRAB9AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL2248318 | 0.74 | ACLY (0.53) | ACLYCYP1A2ADRA2AMAOASLC6A2 | |
| SCHEMBL885867 | 0.73 | DRD1 (0.54) | CYP1A2KDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL14067273 | 0.73 | ALDH1A1 (0.54) | CYP1A2ADRA2AMAOASLC6A2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888127-A | Tri-fused ring HPK1 inhibitor and application thereof | 轩竹生物科技股份有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022188823-A1 | TRICYCLIC HPK1 INHIBITOR AND USE THEREOF | 山东轩竹医药科技有限公司 | 2022-09-15 | — | — | WO | disclosed |