Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 2/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8480332 | 0.84 | CA2 (0.33) | HPGD | |
| SCHEMBL6608329 | 0.72 | HPGD (0.32) | HPGDCTSKEPHX1 | |
| SCHEMBL14896297 | 0.70 | DGAT1 (0.32) | CTSKUSP2SMN1; SMN2 | |
| SCHEMBL2064367 | 0.70 | HPGD (0.33) | HPGDCTSKUSP2SMN1; SMN2EPHX1 | |
| SCHEMBL5568399 | 0.68 | HPGD (0.32) | HPGDCTSKEPHX1 | |
| SCHEMBL2785917 | 0.68 | DGAT1 (0.31) | CTSK | |
| SCHEMBL4623345 | 0.67 | ALDH1A1 (0.33) | SMN1; SMN2 | |
| SCHEMBL2434403 | 0.67 | BTK (0.31) | — | |
| SCHEMBL5421441 | 0.67 | HPGD (0.31) | HPGD | |
| SCHEMBL136090 | 0.67 | HPGD (0.31) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569304-A1 | SUBSTITUTED N-HETEROARYL SPIROLACTAM BIPYRROLIDINES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143148-A1 | SUBSTITUTED N-HETEROARYL SPIROLACTAM BIPYRROLIDINES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-11-17 | — | — | WO | disclosed |