Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RGS12 | O14924 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | HEXA | P06865 | 3/20 | 0.38 |
| ▸ | HEXB | P07686 | 3/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29199650 | 0.88 | HPGD (0.49) | MGMTNPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL14499669 | 0.87 | HPGD (0.50) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL26349201 | 0.86 | KDM4E (0.49) | MGMTKDM4EMEN1ALDH1A1HTT | |
| SCHEMBL30459062 | 0.84 | CYP1B1 (0.53) | KDM4EMEN1NPC1ALDH1A1LMNA | |
| SCHEMBL15096386 | 0.84 | CYP1B1 (0.53) | KDM4EMEN1NPC1ALDH1A1LMNA | |
| SCHEMBL30455266 | 0.84 | CYP1B1 (0.53) | KDM4EMEN1NPC1ALDH1A1LMNA | |
| SCHEMBL26349215 | 0.82 | ALDH1A1 (0.38) | MGMTKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL26349218 | 0.82 | ALDH1A1 (0.52) | MEN1NPC1ALDH1A1LMNARAB9A | |
| SCHEMBL25495612 | 0.80 | MGMT (0.42) | MGMTMGLL | |
| SCHEMBL26349212 | 0.79 | MGMT (0.34) | MGMTKDM4EMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303502-A1 | HETEROARYL AND HETEROCYCLYL COMPOUNDS | SIGILON THERAPEUTICS, INC. | 2023-09-28 | — | — | US | disclosed |
| US-20230303502-A1 | HETEROARYL AND HETEROCYCLYL COMPOUNDS | SIGILON THERAPEUTICS, INC. | 2023-09-28 | — | — | US | disclosed |
| US-20230303502-A1 | HETEROARYL AND HETEROCYCLYL COMPOUNDS | SIGILON THERAPEUTICS, INC. | 2023-09-28 | — | — | US | disclosed |
| EP-4192468-A2 | HETEROARYL AND HETEROCYCLYL COMPOUNDS | Sigilon Therapeutics, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303502-A1 | HETEROARYL AND HETEROCYCLYL COMPOUNDS | CYP3A43, CYP2C9, CYP2C19 | MGMT 2441/4885TERT 1215/4885KDM4E 4396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.